Biphenyl, mixed with biphenyl oxide (3:7)
RTECS #
DV1500000
CAS #
Updated
July 2013
Molecular Weight
324.44
Molecular Formula
C12H10O·C12H10
Synonyms
1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)
Biphenyl-diphenyl ether mixture
Dinil
Dinyl
Diphenyl mixed with diphenyl oxide
Diphyl
Dowtherm
Dowtherm A
Phenyl ether-biphenyl mixture (OSHA)
Phenyl ether-diphenyl mixture
Biphenyl-diphenyl ether mixture
Dinil
Dinyl
Diphenyl mixed with diphenyl oxide
Diphyl
Dowtherm
Dowtherm A
Phenyl ether-biphenyl mixture (OSHA)
Phenyl ether-diphenyl mixture
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 500 mg/24H | mild | 28ZPAK -,271,1972 |
| skin /rabbit | 500 mg/24H | mild | 28ZPAK -,271,1972 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/human | lowest published toxic concentration: 3 ppm | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes | 28ZRAQ -,204,1960 |
| inhalation/human | lowest published toxic concentration: 26.8 mg/m3 | Eye: Conjunctiva irritation Behavioral: Headache Lung, Thorax, or Respiration: Cough | VCVGK* -,308,1984 |
| oral/guinea pig | lethal dose (50 percent kill): 3 gm/kg | 85GMAT -,61,1982 | |
| oral/mouse | lethal dose (50 percent kill): 3200 mg/kg | VCVGK* -,308,1984 | |
| oral/rabbit | lethal dose (50 percent kill): 4200 mg/kg | VCVGK* -,308,1984 | |
| oral/rat | lethal dose (50 percent kill): 2460 mg/kg | 28ZPAK -,271,1972 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 200 µg/m3/24H/70D- continuous | Behavioral: Muscle contraction or spasticity Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | GISAAA 26(5),3,1961 |
| inhalation/rat | lowest published toxic concentration: 20 mg/m3/4H/122D- intermittent | Lung, Thorax, or Respiration: Emphysema Blood: Change in clotting factors Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,308,1994 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/70D- continuous | Behavioral: Muscle weakness Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | VCVGK* -,308,1994 |
| oral/rat | lowest published toxic dose: 130 mg/kg/26W- intermittent | Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ATORAI -,1,1948 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| TOXICOLOGY REVIEW | ATORAI -,-,1948 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1 ppm (7 mg/m3) (vapor) | DTLVS* 3,206,1971 |
| Occupational Exposure Limit-MEXICO | time-weighted average 1 ppm (7 mg/m3) (vapor), 2004 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 10 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 1 ppm (7 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 7 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1 ppm (7 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1 ppm (7 mg/m3), vapor | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1 ppm (7 mg/m3), vapor | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1 ppm (7 mg/m3), vapor | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1 ppm (7 mg/m3), vapor | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL ETHER-BIPHENYL MIXTURE, vapor-air | 10H time-weighted average 1 ppm | NIOSH* DHHS#92-100,1992 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Phenyl ether-diphenyl mixture, 2013 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health