Benzene, 1,2,4-trimethyl-

RTECS #

DC3325000

CAS #

95-63-6
See: NMAM or OSHA Methods

Updated

July 2013

Molecular Weight

120.21

Molecular Formula

C₉H₁₂

Synonyms

1,2,4-Trimethylbenzene
as-Trimethylbenzene
Asymmetrical trimethylbenzene
Benzene, 1,2,5-trimethyl-
Pseudocumene
Pseudocumol
psi-Cumene

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
sister chromatid exchange	intraperitoneal/mouse	900 mg/kg	MUREAV 412,299,1998

Route/Organism	Dose	Effect	Reference
inhalation/rat	lethal concentration (50 percent kill): 18000 mg/m³/4H		VCVGH* -,175,1990
intraperitoneal/guinea pig	lowest published lethal dose: 1.5 mL/kg		VCVGH* -,176,1990
intraperitoneal/guinea pig	lowest published lethal dose: 1788 mg/kg		AMIHBC 9,227,1954
intraperitoneal/rat	lethal dose (30 percent kill): 5 mL/kg	Lung, Thorax, or Respiration: Other changes Vascular: Regional or general arteriolar or venous dilation	VCVGH* -,176,1990
intraperitoneal/rat	lowest published lethal dose: 1752 mg/kg		85KYAH 11,1258,1989
oral/mouse	lethal dose (50 percent kill): 6900 mg/kg		VCVGH* -,175,1990
oral/rat	lethal dose (50 percent kill): 5 gm/kg		85JCAE -,34,1986

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 20 mg/m³/24H/17W- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases	GISAAA 44(5),15,1979
inhalation/rat	lowest published toxic concentration: 100 ppm/6H/20D- intermittent	Behavioral: Change in motor activity (specific assay) Behavioral: Analgesia Behavioral: Alteration of operant conditioning	NRTXDN 22,79,2001
inhalation/rat	lowest published toxic concentration: 20 mg/m³/16W- continuous	Kidney, Ureter, and Bladder: Other changes in urine composition	VCVGH* -,176,1990
oral/rat	lowest published toxic dose: 19600 mg/kg/4W- intermittent	Brain and Coverings: Recordings from specific areas of CNS Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGH* -,176,1990
oral/rat	lowest published toxic dose: 10 gm/kg/4W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TIHEEC 1(3),67,1985
oral/rat	lowest published toxic dose: 6400 mg/kg/8W- intermittent	Peripheral Nerve and Sensation: Recording from afferent nerve Peripheral Nerve and Sensation: Recording from peripheral motor nerve Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JJATDK 13,123,1993

Organization	Standard	Reference
TOXICOLOGY REVIEW		MUREAV 584,1,2005

Organization	Standard	Reference
Occupational Exposure Limit-DENMARK	time-weighted average 20 ppm (100 mg/m³), MAY2011
Occupational Exposure Limit-EC	time-weighted average 100 mg/m³ (20 ppm), JUN2000
Occupational Exposure Limit-FRANCE	VLE 20 ppm (100 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 20 ppm (100 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 100 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 20 ppm (100 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 25 ppm (120 mg/m³), MAY2012
Occupational Exposure Limit-MEXICO	time-weighted average 25 ppm (125 mg/m³);short term exposure limit 35 ppm (170 mg/m³), 2004
Occupational Exposure Limit-NORWAY	time-weighted average 20 ppm (100 mg/m³), JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 10 mg/m³, short term exposure limit 30 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 25 ppm (120 mg/m³);short term exposure limit 35 ppm (170 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 20 ppm (100 mg/m³), KZG-week 40 ppm (200 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 100 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 25 ppm (125 mg/m³), OCT2007

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code B0044; Number of Industries 47; Total Number of Facilities 3684; Number of Occupations 42; Total Number of Employees Exposed 65953; Total Number of Female Employees Exposed 9768
National Occupational Hazard Survey 1974	Hazard Code B0044; Number of Industries 2; Total Number of Facilities 33; Number of Occupations 13; Total Number of Employees Exposed 3186

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8911
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018