Benzene, p-dinitro-
RTECS #
CZ7525000
CAS #
Updated
March 2019
Molecular Weight
168.12
Molecular Formula
C6H4N2O4
Synonyms
1,4-Dinitrobenzene
Benzene, 1,4-dinitro- (9CI)
Dithane A-4
p-Dinitrobenzene
p-Dinitrobenzene (ACGIH:OSHA)
Benzene, 1,4-dinitro- (9CI)
Dithane A-4
p-Dinitrobenzene
p-Dinitrobenzene (ACGIH:OSHA)
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
mutation in microorganisms | /Salmonella typhimurium | 5 µg/plate (+enzymatic activation step) | CRNGDP 6,727,1985 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | lethal dose (50 percent kill): 56 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | JPETAB 80,31,1944 |
oral/cat | lowest published lethal dose: 29 mg/kg | 85KYAH 11,516,1989 | |
oral/rat | lowest published toxic dose: 5 mg/kg | Lung, Thorax, or Respiration: Cyanosis Blood: Changes in spleen | TXAPA9 92,54,1988 |
oral/rat | lowest published lethal dose: 50 mg/kg | Eye: Other eye effects Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | NTIS** OTS0546024 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.15 ppm (skin) | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | RTOPDW 60,120,2011 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.15 ppm (1 mg/m3) (skin) | DTLVS* 3,92,1971 |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.15 ppm (1 mg/m3), JUL2008 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.15 ppm (1 mg/m3), skin, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.15 ppm (1 mg/m3), FEB2006 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.15 ppm (1 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.15 ppm (1 mg/m3), skin, MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.15 ppm (1 mg/m3), skin, 2006 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.15 ppm (1 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 0,15 ppm (1 mg/m3), JUL2005 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 0.15 ppm (1 mg/m3);short term exposure limit 0.3 ppm (2 mg/m3), Skin, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.15 ppm (1 mg/m3), KZG-week 0.3 ppm (2 mg/m3), skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1 mg/m3, 2003 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.15 ppm (1 mg/m3);short term exposure limit 0.5 ppm (3.5 mg/m3), skin, OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-DINITROBENZENE-air | 10H time-weighted average 1 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health