2H-Azepin-2-one, hexahydro-

RTECS #

CM3675000

CAS #

105-60-2
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

113.18

Molecular Formula

C₆H₁₁NO

Synonyms

1,6-Hexolactam
1-Aza-2-cycloheptanone
2-Azacycloheptanone
2H-Azepin-7-one, hexahydro-
2-Ketohexamethyleneimine
2-Ketohexamethylenimine
2-Oxohexamethyleneimine
2-Oxohexamethylenimine
2-Perhydroazepinone
6-Aminocaproic acid lactam
6-Aminohexanoic acid cyclic lactam
6-Caprolactam
6-Hexanelactam
A1030
Aminocaproic lactam
Caprolactam
Caprolactam monomer
Caprolactam, fume
Caprolattame (French)
Capron PK4
Cyclohexanone iso-oxime
e-Kaprolaktam (Czech)
epsilon-Caprolactam
epsilon-Caprolactam (ACGIH)
Epsylon kaprolaktam (Polish)
Extrom 6N
Hexahydro-2-azepinone
Hexahydro-2H-azepin-2-one (9CI)
Hexamethylenimine, 2-oxo-
Hexanoic acid, 6-amino-, cyclic lactam
Hexanoic acid, 6-amino-, lactam
Hexanolactam
Hexanone isoxime
Hexanonisoxim (German)
Kapromine
NCI-C50646
omega-Caprolactam
Stilon

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	20 mg/24H	moderate	85JCAE -,883,1986
skin /rabbit	500 mg/24H	mild	85JCAE -,883,1986

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
body fluid assay	ovary/rat	76 mg/kg	MUREAV 143,263,1985
Cytogenetic Analysis	lymphocyte/human	270 mg/L	PMRSDJ 5,457,1985
Cytogenetic Analysis	lung/hamster	8 gm/L	PMRSDJ 5,427,1985
DNA Damage	intraperitoneal/rat	580 mg/kg	MUREAV 224,379,1989
DNA Damage	intraperitoneal/mouse	580 mg/kg	MUREAV 224,379,1989
DNA inhibition	fibroblast/human	1 mmol/L	NEOLA4 33,699,1986
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	400 mg/L	PMRSDJ 5,271,1985
micronucleus test	multiple/non-mammalian species	100 ppm	MUTAEX 4,17,1989
morphological transform	embryo/hamster	100 mg/L	TIVIEQ 2,103,1988
morphological transform	embryo/mouse	2500 mg/L	PMRSDJ 5,639,1985
mutation in microorganisms	/Saccharomyes cerevisiae	100 mg/L (+/-enzymatic activation step)	PMRSDJ 5,271,1985
phage inhibition capacity	/Escherichia coli	1950 µg/well	MUREAV 260,349,1991
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	5 mmol/L	MUREAV 224,339,1989
sex chromosome loss and nondisjunction	lymphocyte/human	25 mmol/L	MUREAV 224,333,1989
sister chromatid exchange	ovary/hamster	125 mmol/L	MUREAV 224,333,1989
specific locus test	oral/Drosophila melanogaster	5 mmol/L	PMRSDJ 5,313,1985
specific locus test	intraperitoneal/mouse	500 mg/kg	MUREAV 224,369,1989
sperm morphology	inhalation/rat	125 mg/m³/10W	GTPZAB 19(10),40,1975

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	125 mg/m³/24H (76D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	GTPZAB 19(10),40,1975
inhalation/rat	473 mg/m³/4H (1-5D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on embryo or fetus: Fetal death	GISAAA 34(7),25,1969
inhalation/rat	139 mg/m³/4H (6-12D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	GISAAA 34(7),25,1969
inhalation/rat	473 mg/m³/4H (60D prior to copulation)	Reproductive: Maternal effects: Menstrual cycle changes or disorders	GTPZAB 13(10),22,1969
oral/rabbit	3450 mg/kg (6-28D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	JJATDK 7,317,1987
oral/rabbit	2500 mg/kg (6-15D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** OTS0537802
oral/rat	10 gm/kg (6-15D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	JJATDK 7,317,1987
oral/rat	10 gm/kg (6-15D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** OTS0537802
oral/rat	10 gm/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	NTIS** OTS0557708

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 100 ppm	Lung, Thorax, or Respiration: Cough	AIHAAP 34,384,1973
inhalation/mouse	lethal concentration (50 percent kill): 450 mg/m³	Behavioral: Muscle contraction or spasticity	GTPZAB 10(10),54,1966
inhalation/mouse	lethal concentration (50 percent kill): 450 mg/m³		TOVEFN (1),20,2001
inhalation/rat	lethal concentration (50 percent kill): 300 mg/m³		TOVEFN (1),20,2001
inhalation/rat	lethal concentration (50 percent kill): 300 mg/m³/2H		85GMAT -,32,1982
intraperitoneal/mouse	lethal dose (50 percent kill): 650 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Antipsychotic Behavioral: Analgesia	JPMSAE 60,1058,1971
intraperitoneal/rat	lowest published lethal dose: 800 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Body temperature decrease	BJIMAG 11,1,1954
intravenous/mouse	lethal dose (50 percent kill): 480 mg/kg		IMEMDT 39,247,1986
intravenous/rabbit	Lethal dose: >300 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Body temperature decrease	BJIMAG 11,1,1954
oral/mouse	lethal dose (50 percent kill): 930 mg/kg	Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea	GTPZAB 10(10),54,1966
oral/rat	lethal dose (50 percent kill): 1210 mg/kg	Eye: Chromodacryorrhea Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Body temperature decrease	NTPTR* NTP-TR-214,1982
skin/rabbit	lethal dose (50 percent kill): 1410 µL/kg		AIHAAP 30,470,1969
skin/rat	lethal dose (50 percent kill): >2 gm/kg		NTIS** OTS0557720
subcutaneous/frog	lowest published lethal dose: 2800 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold	AEXPBL 50,199,1903
subcutaneous/guinea pig	lowest published lethal dose: 950 mg/kg		MELAAD 43,124,1952
subcutaneous/mouse	lethal dose (50 percent kill): 750 mg/kg		IMEMDT 39,247,1986
unreported route/mouse	lethal dose (50 percent kill): 930 mg/kg	Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased	GISAAA 55(10),33,1990
unreported route/rabbit	lethal dose (50 percent kill): 1 gm/kg	Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased	GISAAA 55(10),33,1990
unreported route/rat	lethal dose (50 percent kill): 580 mg/kg	Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased	GISAAA 55(10),33,1990

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 243 mg/m³/6H/13W- intermittent	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes	TOSCF2 44,197,1998
inhalation/rat	lowest published toxic concentration: 5960 mg/kg/82D- continuous	Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GISAAA 33(1),22,1968
intraperitoneal/rat	lowest published toxic dose: 9100 mg/kg/26W- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in other cell count (unspecified) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	MEPAAX 18,357,1967
oral/rat	lowest published toxic dose: 42 gm/kg/8W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ARZNAD 9,9,1959
oral/rat	lowest published toxic dose: 6750 mg/kg/2W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0555505

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³ (inhal, vapor)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not suspected as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal NO EVIDENCE	IMEMDT 39,247,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal No Evidence	IMEMDT 71,383,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 39,247,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 71,383,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 4	IMEMDT 71,383,1999
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		TOLED5 199,203,2010
TOXICOLOGY REVIEW		FCTOD7 55,596,2013
TOXICOLOGY REVIEW		FCTOD7 109,1,2017
TOXICOLOGY REVIEW		RTOPDW 55,43,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³ (dust and vapor), JUL2008
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³ (dust), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 mg/m³;KZW 40 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³ (dust), MAR2002
Occupational Exposure Limit-BELGIUM	time-weighted average 2.2 ppm (10 mg/m³), (vapor), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 8.7 ppm (40 mg/m³) (vapor), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 mg/m³ (dust), MAY2011
Occupational Exposure Limit-DENMARK	time-weighted average 2 ppm (10 mg/m³) (vapor), MAY2011
Occupational Exposure Limit-EC	time-weighted average 10 mg/m³;short term exposure limit 40 mg/m³ (dust, vapor), JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 10 mg/m³, short term exposure limit 40 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 mg/m³ (dust, vapor), VLE 40 mg/m³ (dust, vapor), FEB2006
Occupational Exposure Limit-GERMANY	MAK 5 mg/m³ (dust, vapor, inhal.), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 10 mg/m³, short term exposure limit 40 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 1 mg/m³, dust, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³, 2006
Occupational Exposure Limit-KOREA	time-weighted average 5 ppm (20 mg/m³), short term exposure limit 10 ppm (40 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1 mg/m³ (dust), 2004
Occupational Exposure Limit-MEXICO	time-weighted average 5 ppm (20 mg/m³);short term exposure limit 3 mg/m³ (vapor), 2004
Occupational Exposure Limit-MEXICO	short term exposure limit 10 ppm (40 mg/m³) (vapor), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 ppm (23 mg/m³); short term exposure limit 10 ppm (46 mg/m³) (vapor), JAN2002
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 mg/m³; short term exposure limit 3 mg/m³ (dust), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 ppm (25 mg/m³), moist, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 10 mg/m³ (dust), JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 10 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 5 mg/m³;short term exposure limit 10 mg/m³, (dust, vapour), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1 mg/m³ (dust), 2003
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 20 mg/m³ (fume), 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 mg/m³; short term exposure limit 3 mg/m³ (dust), OCT2007
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 mg/m³; short term exposure limit 20 mg/m³ (dust, vapor), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPROLACTAM, dust-air	10H time-weighted average 1 mg/m³;short term exposure limit 3 mg/m³	NIOSH* DHHS #95-121,1995
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPROLACTAM, vapor-air	10H time-weighted average 0.22 ppm;short term exposure limit 0.66 ppm	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code 83732; Number of Industries 12; Total Number of Facilities 812; Number of Occupations 19; Total Number of Employees Exposed 25091; Total Number of Female Employees Exposed 8291
National Occupational Hazard Survey 1974	Hazard Code 83732; Number of Industries 14; Total Number of Facilities 955; Number of Occupations 14; Total Number of Employees Exposed 6208

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health