Arsine
RTECS #
CG6475000
CAS #
Updated
December 2018
Molecular Weight
77.95
Molecular Formula
AsH3
Synonyms
Arsenic hydrid
Arsenic hydride
Arsenic trihydride
Arseniuretted hydrogen
Arsenous hydride
Arsenowodor (Polish)
Arsenwasserstoff (German)
Arsine (ACGIH:OSHA)
Hydrogen arsenide
Arsenic hydride
Arsenic trihydride
Arseniuretted hydrogen
Arsenous hydride
Arsenowodor (Polish)
Arsenwasserstoff (German)
Arsine (ACGIH:OSHA)
Hydrogen arsenide
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/cat | Lowest published lethal concentration: 150 mg/m3/20M | HBAMAK 4,1306,1935 | |
inhalation/Dog | lethal concentration (50 percent kill): 350 mg/m3/30M | NTIS** PB158-508 | |
inhalation/Dog | lethal concentration (50 percent kill): 0.5 mg/m3/15M | VCVN5* -,87,1993 | |
inhalation/domestic animal | lethal concentration (50 percent kill): 1 gm/m3/10M | NTIS** PB158-508 | |
inhalation/frog | Lowest published lethal concentration: 4500 mg/m3/3H | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Altered sleep time (including change in righting reflex) Cardiac: Other changes | AEXPBL 80,288,1917 |
inhalation/human | Lowest published lethal concentration: 250 mg/m3/30M | Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Nausea or vomiting | HBTME* -,367,2007 |
inhalation/human | lowest published toxic concentration: 3 ppm | Blood: Pigmented or nucleated red blood cells Blood: Other hemolysis with or without anemia | AMIHAB 21,132,1960 |
inhalation/human | Lowest published lethal concentration: 25 ppm/30M | Blood: Other hemolysis with or without anemia Endocrine: Change in GH | AEHLAU 19,133,1969 |
inhalation/human | Lowest published lethal concentration: 300 ppm/5M | TABIA2 3,231,1933 | |
inhalation/man | lowest published toxic concentration: 325 µg/m3 | Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Hematuria | AEHLAU 34,224,1979 |
inhalation/monkey | Lowest published lethal concentration: 600 mg/m3/1H | HBAMAK 4,1306,1935 | |
inhalation/mouse | lethal concentration (50 percent kill): 250 mg/m3/10M | NTIS** PB158-508 | |
inhalation/mouse | lethal concentration (50 percent kill): 0.5 mg/m3/2M | VCVN5* -,87,1993 | |
inhalation/mouse | lethal concentration (50 percent kill): 0.1 mg/m3/15M | VCVN5* -,87,1993 | |
inhalation/mouse | lethal concentration (50 percent kill): 0.05 gm/m3/2H | TPKVAL 9,7,1967 | |
inhalation/mouse | lethal concentration (50 percent kill): 17.2 ppm/2H | TPKVAL 9,7,1967 | |
inhalation/mouse | Lowest published lethal concentration: 0.63 ppm/30M | TOXID9 72,160,2003 | |
inhalation/mouse | Lowest published lethal concentration: 0.5 ppm/1H | TOXID9 72,160,2003 | |
inhalation/mouse | Lowest published lethal concentration: 0.13 ppm/4H | TOXID9 72,160,2003 | |
inhalation/mouse | Lowest published lethal concentration: 0.06 ppm/8H | TOXID9 72,160,2003 | |
inhalation/rabbit | lethal concentration (50 percent kill): 200 ppm/10M | ENTOX* -,173,2005 | |
inhalation/rabbit | lethal concentration (50 percent kill): 0.4 mg/m3/15M | Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia Gastrointestinal: Necrotic changes Kidney, Ureter, and Bladder: Hematuria | VCVN5* -,87,1993 |
inhalation/rabbit | lethal concentration (50 percent kill): 650 mg/m3/10M | NTIS** PB158-508 | |
inhalation/rat | lethal concentration (50 percent kill): 0.3 mg/m3/15M | VCVN5* -,87,1993 | |
inhalation/rat | lethal concentration (50 percent kill): 390 mg/m3/10M | NTIS** PB158-508 | |
inhalation/rat | lethal concentration (50 percent kill): 240 ppm/30M | Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria Blood: Hemorrhage | ENTOX* -,173,2005 |
inhalation/rat | lethal concentration (50 percent kill): 178 ppm/1H | Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria Blood: Hemorrhage | ENTOX* -,173,2005 |
inhalation/rat | lethal concentration (50 percent kill): 45 ppm/4H | Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria Blood: Hemorrhage | ENTOX* -,173,2005 |
inhalation/rat | lethal concentration (50 percent kill): 120 ppm/10M | Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria Blood: Hemorrhage | ENTOX* -,173,2005 |
intraperitoneal/cat | lethal dose (50 percent kill): 2 mg/kg | BJPCAL 1,287,1946 | |
intraperitoneal/domestic animal | lethal dose (50 percent kill): 3 mg/kg | BJPCAL 1,287,1946 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 3 mg/kg | BJPCAL 1,287,1946 | |
intraperitoneal/rabbit | lethal dose (50 percent kill): 2500 µg/kg | BJPCAL 1,287,1946 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/hamster | lowest published toxic concentration: 2500 ppm/6H/28D- intermittent | Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Other changes | FAATDF 14,776,1990 |
inhalation/mouse | lowest published toxic concentration: 5 ppm/6H/14D- intermittent | Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Changes in other cell count (unspecified) | FAATDF 14,776,1990 |
inhalation/mouse | lowest published toxic concentration: 500 ppb/12W- intermittent | Endocrine: Changes in spleen weight Blood: Changes in spleen Blood: Changes in leukocyte (WBC) count | TXAPA9 97,173,1989 |
inhalation/mouse | lowest published toxic concentration: 2.5 ppm/10D- intermittent | Endocrine: Changes in spleen weight | NTPTR* ##TER87038 |
inhalation/rat | lowest published toxic concentration: 2500 ppm/6H/14D- intermittent | Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Other changes | FAATDF 14,776,1990 |
inhalation/rat | lowest published toxic concentration: 500 ppm/6H/28D- intermittent | Endocrine: Changes in spleen weight Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | FAATDF 14,776,1990 |
inhalation/rat | lowest published toxic concentration: 500 ppm/6H/90D- intermittent | Endocrine: Changes in spleen weight Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count | FAATDF 14,776,1990 |
inhalation/rat | lowest published toxic concentration: 0.3 mg/m3/24H/13W- continuous | Kidney, Ureter, and Bladder: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in leukocyte (WBC) count | VCVN5* -,92,1989 |
inhalation/rat | lowest published toxic concentration: 2.5 ppm/10D- intermittent | Endocrine: Changes in spleen weight Blood: Changes in cell count (unspecified) | NTPTR* ##TER87038 |
inhalation/rat | lowest published toxic concentration: 5 ppm/12D- intermittent | Blood: Other changes | NTPTR* ##TER87038 |
intraperitoneal/mouse | lowest published toxic dose: 12 mg/kg/10D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BJPCAL 1,287,1946 |
intraperitoneal/rabbit | lowest published toxic dose: 5500 µg/kg/11D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BJPCAL 1,287,1946 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.005 ppm | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Sufficient Evidence | IMEMDT 23,39,1980 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 1 | IMEMDT 100C,85,2012 |
TOXICOLOGY REVIEW | NEJMAG 291,1171,1974 | |
TOXICOLOGY REVIEW | AMIHAB 21,132,1960 | |
TOXICOLOGY REVIEW | PTPAD4 1,189,1976 | |
TOXICOLOGY REVIEW | AJMEAZ 38,409,1965 | |
TOXICOLOGY REVIEW | JTEHD6 46,399,1995 | |
TOXICOLOGY REVIEW | ENTOX* -,173,2005 | |
TOXICOLOGY REVIEW | REPTED 23,428,2007 | |
TOXICOLOGY REVIEW | HBTME* ,367,2007 | |
TOXICOLOGY REVIEW | HTOPA* 1,701,2002 | |
TOXICOLOGY REVIEW | BLREV* 3,71,1989 | |
TOXICOLOGY REVIEW | HTCWA* 2,109, | |
TOXICOLOGY REVIEW | FCTOD7 107,406,2017 | |
TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.05 ppm (0.2 mg/m3) | DTLVS* 3,16,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.05 ppm (0.2 mg/m3), JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.05 ppm (0.16 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.05 ppm (0.2 mg/m3);KZW 0.25 ppm (1 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.05 ppm (0.16 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.01 ppm (0.03 mg/m3), carc, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.01 mg(As)/m3, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.05 ppm (0.2 mg/m3), VLE 0.2 ppm (0.8 mg/m3), FEB2006 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 0.2 mg/m3, short term exposure limit 0.8 mg/m3, Skin, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.01 ppm (0.03 mg(As)/m3), carc, NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.01 ppm (0.032 mg/m3), MAY2012 | |
Occupational Exposure Limit-JAPAN | ceiling concentration 0.1 ppm (0.32 mg/m3), MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.05 ppm (0.2 mg/m3), 2006 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.2 mg(As)/m3, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.05 ppm (0.2 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.05 ppm (0.16 mg/m3), JAN2002 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.003 ppm (0.01 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 0,05 ppm (0,16 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.2 mg/m3, MAC(short term exposure limit) 0.6 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 0.1 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 0.02 ppm (0.05 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.05 ppm (0.16 mg/m3), JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 0.05 ppm (0.2 mg/m3), JAN1993 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.2 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.05 ppm (0.5 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 0.05 ppm (0.2 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.05 ppm (0.16 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.05 ppm (0.2 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.05 ppm (0.2 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.05 ppm (0.2 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.05 ppm (0.2 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSINE-air | Carcinogen ceiling concentration 0.002 mg/m3/15M | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 07580; Number of Industries 5; Total Number of Facilities 293; Number of Occupations 11; Total Number of Employees Exposed 3933; Total Number of Female Employees Exposed 1254 | |
National Occupational Hazard Survey 1974 | Hazard Code 07580; Number of Industries 4; Total Number of Facilities 55; Number of Occupations 5; Total Number of Employees Exposed 586 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health