Aniline, N,N-dimethyl-
RTECS #
BX4725000
CAS #
Updated
March 2018
Molecular Weight
121.20
Molecular Formula
C8H11N
Synonyms
(Dimethylamino)benzene
Benzenamine, N,N-dimethyl-
Dimethylaniline
Dimethylaniline (ACGIH:OSHA)
Dwumetyloanilina (Polish)
N,N-Dimethylaniline
N,N-Dimethylaniline (OSHA)
N,N-Dimethylbenzenamine
N,N-Dimethylphenylamine
NCI-C56428
NL 63-10P
Versneller NL 63/10
Benzenamine, N,N-dimethyl-
Dimethylaniline
Dimethylaniline (ACGIH:OSHA)
Dwumetyloanilina (Polish)
N,N-Dimethylaniline
N,N-Dimethylaniline (OSHA)
N,N-Dimethylbenzenamine
N,N-Dimethylphenylamine
NCI-C56428
NL 63-10P
Versneller NL 63/10
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 20 mg/24H | moderate | 85JCAE -,461,1986 |
| eye /rabbit | 20 mg | moderate | HPV300 -,-,2001 |
| skin /rabbit | 500 mg | mild | HPV300 -,-,2001 |
| skin /rabbit | 10 mg/24H open irritation test | mild | AIHAAP 23,95,1962 |
| skin /rabbit | 500 mg/24H | mild | 85JCAE -,461,1986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | ovary/hamster | 83 mg/L | EMMUEG 13,60,1989 |
| DNA Damage | intraperitoneal/rat | 485 mg/kg | EMMUEG 21,349,1993 |
| DNA Damage | intraperitoneal/mouse | 242 mg/kg | HPV300 -,-,2001 |
| micronucleus test | lung/hamster | 900 µmol/L | EMMUEG 21,349,1993 |
| micronucleus test | ovary/hamster | 140 mg/L (-enzymatic activation step) | HPV300 -,-,2001 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 20 mg/L | NTPTR* NTP-TR-360,1989 |
| sister chromatid exchange | ovary/hamster | 30 mg/L | EMMUEG 13,60,1989 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | 2920 mg/kg (7-14D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV300 -,-,2001 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 15450 mg/kg/2Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Tumors | NTPTR* NTP-TR-360,1989 |
| oral/mouse | lowest published toxic dose: 15450 mg/kg/103W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | NTIS** PB90-227240/AS |
| oral/mouse | lowest published toxic dose: 15450 mg/kg/103W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | HPV300 -,-,2001 |
| oral/rat | lowest published toxic dose: 15450 mg/kg/2Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Tumors | NTPTR* NTP-TR-360,1989 |
| oral/rat | lowest published toxic dose: 1545 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia Tumorigenic: Increased incidence of tumors in susceptible strains | HPV300 -,-,2001 |
| oral/rat | lowest published toxic dose: 15450 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Blood: Tumors | NTIS** PB90-227240/AS |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | Lowest published lethal concentration: 980 mg/m3/30M | HPV300 -,-,2001 | |
| inhalation/rat | Lowest published lethal concentration: 250 mg/m3/4H | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement | GISAAA 37(4),35,1972 |
| inhalation/rat | Lowest published lethal concentration: 250 mg/m3/4H | HPV300 -,-,2001 | |
| inhalation/rat | Lowest published lethal concentration: 980 mg/m3/30M | HPV300 -,-,2001 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 960 mg/kg | HPV300 -,-,2001 | |
| intraperitoneal/mouse | lowest published toxic dose: 60 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | HPV300 -,-,2001 |
| intraperitoneal/rat | lowest published toxic dose: 39 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | HPV300 -,-,2001 |
| oral/cat | lowest published toxic dose: 50 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | HPV300 -,-,2001 |
| oral/Dog | lowest published toxic dose: 50 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | HPV300 -,-,2001 |
| oral/guinea pig | lowest published lethal dose: 2000 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression | HPV300 -,-,2001 |
| oral/human | lowest published lethal dose: 50 mg/kg | HPV300 -,-,2001 | |
| oral/human | lowest published lethal dose: 50 mg/kg | Gastrointestinal: Nausea or vomiting Gastrointestinal: Other changes | NCPBBY Jan/Feb,1969 |
| oral/mouse | lethal dose (50 percent kill): 1440 mg/kg | HPV300 -,-,2001 | |
| oral/mouse | lowest published lethal dose: 350 mg/kg | HPV300 -,-,2001 | |
| oral/rat | lethal dose (50 percent kill): 951 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Cyanosis | NTIS** OTS0571982 |
| oral/rat | lethal dose (50 percent kill): 1120 mg/kg | HPV300 -,-,2001 | |
| skin/guinea pig | lethal dose (50 percent kill): >20 mL/kg | Skin: After systemic exposure: Dermatitis, other | NTIS** OTS0571982 |
| skin/rabbit | lethal dose (50 percent kill): 1770 µL/kg | AIHAAP 23,95,1962 | |
| skin/rabbit | lethal dose (50 percent kill): 1770 mg/kg | HPV300 -,-,2001 | |
| subcutaneous/guinea pig | lowest published lethal dose: 2000 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression | HPV300 -,-,2001 |
| subcutaneous/rat | lowest published lethal dose: 100 mg/kg | 85GMAT -,55,1982 | |
| subcutaneous/rat | lowest published lethal dose: 100 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression | HPV300 -,-,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 10700 µg/m3/5H/17W- intermittent | Blood: Pigmented or nucleated red blood cells Blood: Methemoglobinemia- Carboxhemoglobinemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | GISAAA 37(4),35,1972 |
| inhalation/rat | lowest published toxic concentration: 300 µg/m3/24H/14W- continuous | Behavioral: Muscle contraction or spasticity Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count | GISAAA 34(3),7,1969 |
| inhalation/rat | lowest published toxic concentration: 0.3 mg/m3/100D- continuous | Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count | HPV300 -,-,2001 |
| oral/mouse | lowest published toxic dose: 2812.5 mg/kg/15D- intermittent | Endocrine: Changes in spleen weight | HPV300 -,-,2001 |
| oral/mouse | lowest published toxic dose: 9000 mg/kg/12D- intermittent | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands | HPV300 -,-,2001 |
| oral/mouse | lowest published toxic dose: 4500 mg/kg/3D- intermittent | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands | HPV300 -,-,2001 |
| oral/mouse | lowest published toxic dose: 4062.5 mg/kg/13W- intermittent | Endocrine: Changes in spleen weight Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV300 -,-,2001 |
| oral/mouse | lowest published toxic dose: 2920 mg/kg/8D- intermittent | Behavioral: Tremor Behavioral: Ataxia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV300 -,-,2001 |
| oral/mouse | lowest published toxic dose: 32500 mg/kg/13W- intermittent | Blood: Changes in spleen | JTEHD6 29,77,1990 |
| oral/mouse | lowest published toxic dose: 32500 mg/kg/13W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen | NTPTR* NTP-TR-360,1989 |
| oral/rat | lowest published toxic dose: 1545 mg/kg/103W- intermittent | Blood: Leukemia Tumorigenic: Active as anti-cancer agent | NTIS** PB90-227240/AS |
| oral/rat | lowest published toxic dose: 2 gm/kg/2D- intermittent | Behavioral: Food intake (animal) Behavioral: Ataxia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0571982 |
| oral/rat | lowest published toxic dose: 1100 mg/kg/15D- intermittent | Endocrine: Changes in spleen weight | NTIS** OTS0571982 |
| oral/rat | lowest published toxic dose: 1312.5 mg/kg/14D- intermittent | Endocrine: Changes in spleen weight | HPV300 -,-,2001 |
| oral/rat | lowest published toxic dose: 4500 mg/kg/6D- intermittent | Endocrine: Changes in spleen weight Blood: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV300 -,-,2001 |
| oral/rat | lowest published toxic dose: 4500 mg/kg/3D- intermittent | Endocrine: Changes in spleen weight Blood: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV300 -,-,2001 |
| oral/rat | lowest published toxic dose: 2031.25 mg/kg/13W- intermittent | Endocrine: Changes in spleen weight Blood: Changes in bone marrow not included in above Blood: Changes in spleen | HPV300 -,-,2001 |
| oral/rat | lowest published toxic dose: 32500 mg/kg/13W- intermittent | Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTEHD6 29,77,1990 |
| oral/rat | lowest published toxic dose: 16250 mg/kg/13W- intermittent | Liver: Other changes Blood: Changes in bone marrow not included in above Blood: Changes in spleen | NTPTR* NTP-TR-360,1989 |
| subcutaneous/Dog | lowest published toxic dose: 0.2 gm/kg/3D- intermittent | Behavioral: Food intake (animal) Gastrointestinal: Changes in structure or function of salivary glands Blood: Methemoglobinemia- Carboxhemoglobinemia | HPV300 -,-,2001 |
| subcutaneous/guinea pig | lowest published toxic dose: 436.8 mg/kg/389D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder | HPV300 -,-,2001 |
| subcutaneous/rat | lowest published toxic dose: 1 gm/kg/10D- intermittent | Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | HPV300 -,-,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 10 ppm (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 57,337,1993 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 57,337,1993 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 57,337,1993 |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | MUTAEX 23,271,2008 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | MUREAV 769,34,2014 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
| TOXICOLOGY REVIEW | MUTAEX 32,491,2017 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (25 mg/m3);KZW 20 ppm (100 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (25 mg/m3), MAR2002 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 10 ppm (51 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (25 mg/m3), skin, carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (25 mg/m3), Skin, C3 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 5 ppm (25 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 25 mg/m3, short term exposure limit 100 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (25 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 5 ppm (25 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 ppm (25 mg/m3);short term exposure limit 10 ppm (50 mg/m3) (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (25 mg/m3); short term exposure limit 10 ppm (50 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (25 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (25 mg/m3); short term exposure limit 10 ppm (50 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 40 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.2 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 1 ppm (5 mg/m3);short term exposure limit 2 ppm (10 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (25 mg/m3), KZG-week 10 ppm (50 mg/m3), carc 3, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 5 ppm (25 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 ppm (25 mg/m3);short term exposure limit 10 ppm (50 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (25 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (25 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (25 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (25 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLANILINE-air | 10H time-weighted average 5 ppm (Sk);short term exposure limit 10 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 26335; Number of Industries 15; Total Number of Facilities 1428; Number of Occupations 27; Total Number of Employees Exposed 30480; Total Number of Female Employees Exposed 7448 | |
| National Occupational Hazard Survey 1974 | Hazard Code 26335; Number of Industries 4; Total Number of Facilities 100; Number of Occupations 10; Total Number of Employees Exposed 2456 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health