Allyl alcohol
RTECS #
BA5075000
CAS #
Updated
December 2018
Molecular Weight
58.09
Molecular Formula
C3H6O
Synonyms
1-Propen-3-ol
1-Propenol-3
2-Propen-1-ol
2-Propene-1-ol
2-Propenyl alcohol
3-Hydroxypropene
AA
Alcool allilco (Italian)
Alcool allylique (French)
Allilowy alkohol (Polish)
Allyl alcohol (ACGIH:OSHA)
Allylalkohol (German)
Allylic alcohol
Orvinylcarbinol
Propen-1-ol-3
Propenol
Propenyl alcohol
RCRA waste number P005
Shell unkrautted A
Vinylcarbinol
Weed drench
1-Propenol-3
2-Propen-1-ol
2-Propene-1-ol
2-Propenyl alcohol
3-Hydroxypropene
AA
Alcool allilco (Italian)
Alcool allylique (French)
Allilowy alkohol (Polish)
Allyl alcohol (ACGIH:OSHA)
Allylalkohol (German)
Allylic alcohol
Orvinylcarbinol
Propen-1-ol-3
Propenol
Propenyl alcohol
RCRA waste number P005
Shell unkrautted A
Vinylcarbinol
Weed drench
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /human | 25 ppm | severe | AMIHAB 18,303,1958 |
| eye /rabbit | 20 mg | severe | AJOPAA 29,1363,1946 |
| eye /rabbit | 0.1 mL | HPV111 -,-,2003 | |
| skin /rabbit | 0.5 mL | mild | HPV111 -,-,2003 |
| skin /rabbit | 10 mg/24H open irritation test | JIHTAB 30,63,1948 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in mammalian somatic cells | lung/hamster | 1 µmol/L | CRNGDP 11,497,1990 |
| mutation in mammalian somatic cells | fibroblast/hamster | 58000 ng/L/2H | HPV111 -,-,2003 |
| mutation in microorganisms | /Salmonella typhimurium | 50 µg/plate/45M (+enzymatic activation step) | HPV111 -,-,2003 |
| mutation in microorganisms | /Salmonella typhimurium | 20 µmol/L/90M (+enzymatic activation step) | HPV111 -,-,2003 |
| mutation in microorganisms | /Salmonella typhimurium | 100 µmol/L (+enzymatic activation step) | MUREAV 93,305,1982 |
| mutation in microorganisms | /Salmonella typhimurium | 50 µg/plate (-enzymatic activation step) | TCMUD8 1,259,1980 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 2100 mg/kg (84D male) | Reproductive: Other effects on male Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV111 -,-,2003 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, kidney | Inhibitor Concentration Low: 100 µmol/L/6H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TXCYAC 290,82,2011 |
| In Vitro/Human, kidney | Inhibitor Concentration Low: 100 µmol/L/48H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Other assays | TXCYAC 290,82,2011 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 3.7 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
| inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 1 gm/m3 | GTPZAB 32(10),25,1988 | |
| inhalation/monkey | Lowest published lethal concentration: 1000 ppm/4H | Gastrointestinal: Hypermotility, diarrhea Blood: Hemorrhage Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JAMAAP 98,2269,1932 |
| inhalation/mouse | lethal concentration (50 percent kill): 500 mg/m3/2H | 85GMAT -,17,1982 | |
| inhalation/mouse | lethal concentration (50 percent kill): 500 mg/m3/2H | Cardiac: Other changes Liver: Hepatitis (hepatocellular necrosis), diffuse | VCVGK* -,121,1984 |
| inhalation/rabbit | Lowest published lethal concentration: 1000 ppm/3.5H | Eye: Iritis Lung, Thorax, or Respiration: Dyspnea Blood: Hemorrhage | JAMAAP 98,2269,1932 |
| inhalation/rat | lowest published toxic concentration: 140 mg/m3 | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | VCVGK* -,121,1984 |
| inhalation/rat | lowest published toxic concentration: 200 mg/m3 | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVGK* -,121,1984 |
| inhalation/rat | lethal concentration (50 percent kill): 76 ppm/8H | Lung, Thorax, or Respiration: Acute pulmonary edema | AMIHAB 18,303,1958 |
| inhalation/rat | lethal concentration (50 percent kill): 165 ppm/4H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Hepatitis (hepatocellular necrosis), zonal | HPV111 -,-,2003 |
| inhalation/rat | lethal concentration (50 percent kill): 250 ppm/4H | HPV111 -,-,2003 | |
| intraperitoneal/mouse | lowest published toxic dose: 64 mg/kg | Liver: Liver function tests impaired | ETOPFR 3,129,1997 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 60 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Behavioral: Ataxia | AMIHAB 18,303,1958 |
| intraperitoneal/mouse | lowest published toxic dose: 60 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TXCYAC 325,85,2014 |
| intraperitoneal/mouse | lowest published toxic dose: 64 mg/kg | ETOPFR 3,129,1997 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 37 mg/kg | TXAPA9 83,108,1986 | |
| intraperitoneal/rat | lowest published toxic dose: 5 mg/kg | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | ETOPFR 18,149,2004 |
| intraperitoneal/rat | lowest published toxic dose: 0.62 mg/kg | Liver: Hepatitis (hepatocellular necrosis), zonal Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport | TXCYAC 196,155,2004 |
| intravenous/mouse | lethal dose (50 percent kill): 78 mg/kg | AIPTAK 135,330,1962 | |
| intravenous/rat | lowest published toxic dose: 125 mg/kg | Liver: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | BCPCA6 67,2141,2004 |
| oral/human | lowest published lethal dose: 0.43 mL/kg | Lung, Thorax, or Respiration: Emphysema Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,121,1984 |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 70 mg/kg | GTPZAB 32(10),25,1988 | |
| oral/mouse | lethal dose (50 percent kill): 75 mg/kg | VCVGK* -,121,1984 | |
| oral/mouse | lethal dose (50 percent kill): 96 mg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Behavioral: Ataxia | AMIHAB 18,303,1958 |
| oral/mouse | lethal dose (50 percent kill): 96 mg/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Acute pulmonary edema | HPV111 -,-,2003 |
| oral/rabbit | lethal dose (50 percent kill): 52 mg/kg | NTIS** OTS0571508 | |
| oral/rat | lowest published toxic dose: 50 mg/kg | Liver: Multiple effects | FATOAO 50,100,1987 |
| oral/rat | lowest published toxic dose: 50 mg/kg | Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Liver function tests impaired | FATOAO 50,100,1987 |
| oral/rat | lowest published toxic dose: 0.05 mg/kg | Liver: Hepatitis (hepatocellular necrosis), diffuse Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | VCVGK* -,121,1984 |
| oral/rat | lowest published toxic dose: 60 mg/kg | Gastrointestinal: Ulceration or bleeding from stomach Liver: Hepatitis (hepatocellular necrosis), zonal Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOXID9 66,199,2002 |
| oral/rat | lowest published toxic dose: 0.1 mL/kg | Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | JTPAE7 15,95,2002 |
| oral/rat | lethal dose (50 percent kill): 70 mg/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea | HPV111 -,-,2003 |
| oral/rat | lethal dose (50 percent kill): 99 mg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, and Bladder: Other changes | HPV111 -,-,2003 |
| oral/rat | lethal dose (50 percent kill): 64 mg/kg | HPV111 -,-,2003 | |
| parenteral/frog | lowest published lethal dose: 51 mg/kg | Behavioral: Excitement Gastrointestinal: Nausea or vomiting | AIPTAK 50,296,1935 |
| skin/rabbit | lethal dose (50 percent kill): 89 mg/kg | Lung, Thorax, or Respiration: Respiratory depression Liver: Hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, and Bladder: Other changes | HPV111 -,-,2003 |
| skin/rabbit | lethal dose (50 percent kill): 45 mg/kg | HPV111 -,-,2003 | |
| subcutaneous/rabbit | lowest published lethal dose: 100 mg/kg | BDBU** -,-,1930 | |
| unreported route/Dog | lowest published lethal dose: 4270 µg/kg | Behavioral: Coma Gastrointestinal: Nausea or vomiting Blood: Other changes | JPETAB 25,144,1925 |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 66 mg/kg | GISAAA 51(5),61,1986 | |
| unreported route/rat | lowest published toxic dose: 120 mg/kg | Kidney, Ureter, and Bladder: Other changes in urine composition | TOXID9 44,104,2005 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 60 ppm/7H/13W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AMIHAB 18,303,1958 |
| inhalation/rat | lowest published toxic concentration: 40 ppm/12W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV111 -,-,2003 |
| inhalation/rat | lowest published toxic concentration: 100 ppm/12W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Liver: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV111 -,-,2003 |
| oral/mouse | lowest published toxic dose: 812.5 mg/kg/90D- intermittent | Gastrointestinal: Gastritis | TXCYAC 253,79,2008 |
| oral/mouse | lowest published toxic dose: 3250 mg/kg/90D- intermittent | Gastrointestinal: Gastritis Liver: Hepatitis (hepatocellular necrosis), diffuse | TXCYAC 253,79,2008 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/15W- continuous | Behavioral: Food intake (animal) Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXCYAC 9,29,1978 |
| oral/rat | lowest published toxic dose: 871.5 mg/kg/15W- intermittent | Kidney, Ureter, and Bladder: Renal function tests depressed | HPV111 -,-,2003 |
| oral/rat | lowest published toxic dose: 1470 mg/kg/15W- intermittent | Kidney, Ureter, and Bladder: Renal function tests depressed Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV111 -,-,2003 |
| oral/rat | lowest published toxic dose: 724.5 mg/kg/15W- intermittent | Kidney, Ureter, and Bladder: Changes in kidney weight | HPV111 -,-,2003 |
| oral/rat | lowest published toxic dose: 90 mg/kg/3D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | HETOEA 28,231,2009 |
| oral/rat | lowest published toxic dose: 610 mg/kg/244D- intermittent | Liver: Liver function tests impaired Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | VCVGK* -,121,1994 |
| oral/rat | lowest published toxic dose: 390 mg/kg/90D- intermittent | Liver: Changes in liver weight | TXCYAC 253,79,2008 |
| oral/rat | lowest published toxic dose: 1625 mg/kg/90D- intermittent | Gastrointestinal: Gastritis Liver: Hepatitis (hepatocellular necrosis), diffuse Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | TXCYAC 253,79,2008 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 ppm (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | CHHSA* 9,6,2002 | |
| TOXICOLOGY REVIEW | ENTOX* -,80,2005 | |
| TOXICOLOGY REVIEW | DIMON* 39,678,1993 | |
| TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 | |
| TOXICOLOGY REVIEW | FCTOD7 49,1877,2011 | |
| TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
| TOXICOLOGY REVIEW | MUREAV 786-788,14,2015 | |
| TOXICOLOGY REVIEW | FCTOD7 109,650,2017 | |
| TOXICOLOGY REVIEW | RTOPDW 56,67,2010 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 2 ppm (5 mg/m3) (skin) | DTLVS* 3,7,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 ppm (4.8 mg/m3), short term exposure limit 4 ppm (9.5 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 2 ppm (4.8 mg/m3);KZW 5 ppm (12 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 2 ppm (4.8 mg/m3), MAR2002 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 4 ppm (9.6 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 2 ppm (5 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 4.8 mg/m3 (2 ppm);short term exposure limit 12.1 mg/m3 (5 ppm), skin, JUN2000 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.5 ppm (1.2 mg/m3), short term exposure limit 2 ppm (4.8 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.2 ppm (0.48 mg/m3), VLE 2 ppm (4.8 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 4.8 mg/m3, short term exposure limit 12.1 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 2 ppm (4.8 mg/m3), short term exposure limit 5 ppm (12.1 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 1 ppm (2.4 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 2 ppm (5 mg/m3), short term exposure limit 4 ppm (10 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 2 ppm (5 mg/m3);short term exposure limit 4 ppm (10 mg/m3) (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2 ppm (4.8 mg/m3); short term exposure limit 4 ppm (9.5 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 2 ppm (5 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.5 ppm (1.2 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 10 mg/m3, Skin, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 1 ppm, JUN2003 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 2 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 2 ppm (5 mg/m3);short term exposure limit 6 ppm (14 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 2 ppm (5 mg/m3), KZG-week 4 ppm (10 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 2 ppm (4.8 mg/m3);short term exposure limit 4 ppm, skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 2 ppm (5 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 2 ppm (5 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 2 ppm (5 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 2 ppm (5 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALLYL ALCOHOL-air | 10H time-weighted average 2 ppm (Sk);short term exposure limit 4 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 04370; Number of Industries 3; Total Number of Facilities 60; Number of Occupations 4; Total Number of Employees Exposed 3246; Total Number of Female Employees Exposed 157 | |
| National Occupational Hazard Survey 1974 | Hazard Code 04370; Number of Industries 3; Total Number of Facilities 69; Number of Occupations 7; Total Number of Employees Exposed 780 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health