Acrylic acid
RTECS #
AS4375000
CAS #
Updated
December 2018
Molecular Weight
72.07
Molecular Formula
C3H4O2
Synonyms
2-Propenoic acid (9CI)
Acroleic acid
Acrylic acid (ACGIH)
Acrylic acid, glacial
Ethylenecarboxylic acid
Glacial acrylic acid
Kyselina akrylova (Czech)
Propene acid
Propenoic acid
RCRA waste number U008
Vinylformic acid
Acroleic acid
Acrylic acid (ACGIH)
Acrylic acid, glacial
Ethylenecarboxylic acid
Glacial acrylic acid
Kyselina akrylova (Czech)
Propene acid
Propenoic acid
RCRA waste number U008
Vinylformic acid
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 1 mg | severe | UCDS** 2/2/1965 |
eye /rabbit | 250 µg/24H | severe | 85JCAE -,309,1986 |
skin /rabbit | 500 mg open irritation test | severe | UCDS** 2/2/1965 |
skin /rabbit | 5 mg/24H | severe | 85JCAE -,309,1986 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | lymphocyte/mouse | 450 mg/L | EMMUEG 11,49,1988 |
Cytogenetic Analysis | ovary/hamster | 116 mg/L | FCTOD7 30,505,1992 |
mutation in mammalian somatic cells | other cell types/mouse | 4.56 mmol/l (+/-enzymatic activation step) | HPV063 -,-,2003 |
mutation in mammalian somatic cells | lymphocyte/mouse | 500 mg/L | EMMUEG 11,49,1988 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | 300 ppm (6-20D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects on female | TOSCF2 48,240,1999 |
inhalation/rabbit | 75 ppm (6-18D pregnant) | Reproductive: Other effects on female | HPV063 -,-,2003 |
intraperitoneal/rat | 14340 µg/kg (5-15D pregnant) | Reproductive: Other developmental abnormalities | JDREAF 51,1632,1972 |
intraperitoneal/rat | 7329 µg/kg (5-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | JDREAF 51,1632,1972 |
oral/rat | 169 gm/kg (13W male/13W pre-3W after birth) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Physical | DCTODJ 6,1,1983 |
oral/rat | 43680 mg/kg (multigeneration) | Reproductive: Other effects on female Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** OTS0573007 |
oral/rat | 16800 mg/kg (multigeneration) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | HPV063 -,-,2003 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin/mouse | lowest published toxic dose: 37440 mg/kg/78W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia | EPASR* 8EHQ-0386-0592 |
skin/mouse | toxic dose: 37440 mg/kg/78W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors | EPASR* 8EHQ-0386-0592 |
subcutaneous/mouse | lowest published toxic dose: 2912 mg/kg/52W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application | CBINA8 61,189,1987 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, skin | Inhibitor Concentration Low: 0.08 mL/well/3M | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 28,616,2014 |
inhalation/human | lowest published toxic concentration: 40 mg/m3 | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | TOVEFN (4),23,2000 |
inhalation/monkey | Lethal concentration: >75 ppm/6H | Olfaction: Deviated nasal septum Olfaction: Ulcerated nasal septum | TOXID9 36(1 Pt2),113,1997 |
inhalation/mouse | lethal concentration (50 percent kill): 5300 mg/m3/2H | 85GMAT -,16,1982 | |
inhalation/rat | Lowest published lethal concentration: 4000 ppm/4H | TXAPA9 28,313,1974 | |
inhalation/rat | Lowest published lethal concentration: 4105 mg/m3/1H | Lung, Thorax, or Respiration: Dyspnea | HPV063 -,-,2003 |
intraperitoneal/mouse | lethal dose (50 percent kill): 144 mg/kg | YKKZAJ 104,793,1984 | |
intraperitoneal/rat | lethal dose (50 percent kill): 22 mg/kg | JDREAF 51,1632,1972 | |
oral/mouse | lethal dose (50 percent kill): 2400 mg/kg | Tumorigenic: Active as anti-cancer agent | BIJOAK 34,1196,1940 |
oral/rat | lethal dose (50 percent kill): 33500 µg/kg | 85GMAT -,16,1982 | |
oral/rat | lethal dose (50 percent kill): 1337 mg/kg | Behavioral: Somnolence (general depressed activity) | HPV063 -,-,2003 |
skin/rabbit | lethal dose (50 percent kill): 280 µL/kg | TXAPA9 28,313,1974 | |
skin/rabbit | lethal dose (50 percent kill): 640 mg/kg | Cardiac: Cardiomegaly Lung, Thorax, or Respiration: Acute pulmonary edema Skin: After topical application: Corrosive | HPV063 -,-,2003 |
subcutaneous/mouse | lethal dose (50 percent kill): 1590 mg/kg | JPPMAB 21,85,1969 | |
unreported route/mouse | lethal dose (50 percent kill): 830 mg/kg | GISAAA 49(10),64,1984 | |
unreported route/rabbit | lethal dose (50 percent kill): 250 mg/kg | GISAAA 49(10),64,1984 | |
unreported route/rat | lethal dose (50 percent kill): 1250 mg/kg | GISAAA 49(10),64,1984 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 223 ppm/6H/2W- intermittent | Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 1,271,1981 |
inhalation/mouse | lowest published toxic concentration: 25 ppm/6H/13W- intermittent | Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 1,271,1981 |
inhalation/mouse | lowest published toxic concentration: 225 ppm/6H/10D- intermittent | Olfaction: Other olfaction effects Behavioral: Muscle contraction or spasticity Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0555707 |
inhalation/mouse | lowest published toxic concentration: 25 ppm/13W- intermittent | Olfaction: Other olfaction effects Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV063 -,-,2003 |
inhalation/rat | lowest published toxic concentration: 223 ppm/6H/2W- intermittent | Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 1,271,1981 |
inhalation/rat | lowest published toxic concentration: 75 ppm/6H/13W- intermittent | Olfaction: Other olfaction effects | FAATDF 1,271,1981 |
inhalation/rat | lowest published toxic concentration: 225 ppm/6H/10D- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0555707 |
inhalation/rat | lowest published toxic concentration: 75 ppm/13W- intermittent | Olfaction: Other olfaction effects | HPV063 -,-,2003 |
oral/rat | lowest published toxic dose: 22500 mg/kg/90D- continuous | Behavioral: Fluid intake Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Changes in testicular weight | DCTODJ 6,1,1983 |
oral/rat | lowest published toxic dose: 36000 mg/kg/48W- intermittent | Behavioral: Food intake (animal) Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV063 -,-,2003 |
oral/rat | lowest published toxic dose: 21000 mg/kg/12W- intermittent | Behavioral: Fluid intake | HPV063 -,-,2003 |
oral/rat | lowest published toxic dose: 63000 mg/kg/12W- intermittent | Brain and Coverings: Changes in brain weight Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV063 -,-,2003 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal No Adequate Data | IMEMDT 19,47,1979 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal No Adequate Data | IMEMDT 71,1223,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 19,47,1979 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,1223,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 71,1223,1999 |
TOXICOLOGY REVIEW | ENTOX* -,45,2005 | |
TOXICOLOGY REVIEW | NTAPM* -,727,1995 | |
TOXICOLOGY REVIEW | RTOPDW 54,247,2009 | |
TOXICOLOGY REVIEW | RTOPDW 55,43,2009 | |
TOXICOLOGY REVIEW | RTOPDW 55,52,2009 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACRYLIC ACID-air | 10H time-weighted average 2 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 03570; Number of Industries 74; Total Number of Facilities 4826; Number of Occupations 67; Total Number of Employees Exposed 96535; Total Number of Female Employees Exposed 28146 | |
National Occupational Hazard Survey 1974 | Hazard Code 03570; Number of Industries 44; Total Number of Facilities 1679; Number of Occupations 41; Total Number of Employees Exposed 28576 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health