Acetylene, dichloro-
RTECS #
AP1080000
CAS #
Updated
September 2013
Molecular Weight
94.92
Molecular Formula
C2Cl2
Synonyms
Dichloroacetylene
Dichloroacetylene (ACGIH:OSHA)
Dichloroethyne
Ethyne, dichloro- (9CI)
Dichloroacetylene (ACGIH:OSHA)
Dichloroethyne
Ethyne, dichloro- (9CI)
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in microorganisms | /Salmonella typhimurium | 4000 ppm (+/-enzymatic activation step) | MUREAV 117,21,1983 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 2 ppm/24H/77W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors Blood: Tumors | CRNGDP 5,1411,1984 |
| inhalation/rat | lowest published toxic concentration: 14 ppm/6H/77W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Vascular: Tumors Kidney, Ureter, and Bladder: Kidney tumors | CRNGDP 5,1411,1984 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lethal concentration (50 percent kill): 19 ppm/6H | Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Dyspnea Skin and Appendages: Other: Hair | FCTXAV 13,511,1975 |
| inhalation/mouse | lethal concentration (50 percent kill): 480 mg/m3/1H | VCVGH* -,530,1990 | |
| inhalation/mouse | lethal concentration (50 percent kill): 74 mg/m3/6H | Brain and Coverings: Other degenerative changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | VCVGH* -,530,1990 |
| inhalation/rabbit | Lowest published lethal concentration: 307 ppm/1H | Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | FCTXAV 16,227,1978 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intramuscular/rat | lowest published toxic dose: 850 mg/kg/10W- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath Biochemical: Metabolism (intermediary): Lipids including transport | NRTXDN 13,601,1992 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 0.1 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 39,369,1986 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 71,1381,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 39,369,1986 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,1381,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 71,1381,1999 |
| TOXICOLOGY REVIEW | ARPTDI 45,147,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | NEUCL* 18,741,2000 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD | air-ceiling concentration 0.1 ppm (0.4 mg/m3) | DTLVS* 3,75,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | ceiling concentration 0.1 ppm (0.39 mg/m3), Carcinogen, JUL2008 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 0.1 ppm (0.4 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 0.1 ppm (0.4 mg/m3), carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.1 ppm (0.39 mg/m3), short term exposure limit 0.3 ppm (1.2 mg/m3), NOV2011 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 0.1 ppm (0.4 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | ceiling concentration 0.1 ppm (0.4 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | peak 0.1 ppm (0.4 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 0.1 ppm (0.39 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.1 ppm (0.4 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | short term exposure limit 0.1 ppm (0.39 mg/m3), JUL2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 ppm (0.4 mg/m3), carc 2, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-C 0.4 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | short term exposure limit 0.1 ppm (0.39 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | ceiling concentration 0.1 ppm (0.4 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | ceiling concentration 0.1 ppm (0.4 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLOROACETYLENE-air | Carcinogen ceiling concentration 0.1 ppm | NIOSH* DHHS #95-121,1995 |
| National Occupational Exposure Survey 1983 | Hazard Code X5342; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 3; Total Number of Employees Exposed 61; Total Number of Female Employees Exposed 6 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health