Acetimidic acid, thio-N-((methylcarbamoyl)oxy)-, methyl ester
RTECS #
AK2975000
CAS #
Updated
September 2018
Molecular Weight
162.23
Molecular Formula
C5H10N2O2S
Synonyms
1N-X1179-412
2-Methylthio-acetaldehyd-O-(methylcarbamoyl)-oxim (German)
2-Methylthio-propionaldehyd-O-(methylcarbamoyl)-oxim (German)
3-Thiabutan-2-one, O-(methylcarbamoyl)oxime
Acetimidic acid, N-((methylcarbamoyl)oxy)thio-, methyl ester (8CI)
Acetimidothioic acid, methyl-, N-(methylcarbamoyl) ester
DPX-X1179-412
Du Pont insecticide 1179
Dupont 1179
ENT 27,341
Ethanimidothioic acid, N-(((methylamino)carbonyl)oxy)-, methyl ester (9CI)
IN 1179
Insecticide 1,179
Lannate
Lannate 10L candidate
Lannate L
Lannate LV
Mesomile
Methomex
Methomyl
Methomyl (ACGIH)
Methyl N-(((methylamino)carbonyl)oxy)ethanimidothioate
Methyl O-(methylcarbamoyl)thiolacethohydroxamate
Methyl-N-((methylcarbamoyl)oxy)thioacetimidate
Metomil (Italian)
N-(((Methylamino)carbonyl)oxy)ethanimidothioic acid methyl ester
N-((Methylcarbamoyl)oxy)thioacetimidic acid methyl ester
NU-Bait II
Nudrin
RCRA waste number P066
SD 14999
S-Methyl N-(methylcarbamoyloxy) thioacetimidate
S-Methyl N-(methylcarbamoyloxy)thioacetimidate
WL 18236
2-Methylthio-acetaldehyd-O-(methylcarbamoyl)-oxim (German)
2-Methylthio-propionaldehyd-O-(methylcarbamoyl)-oxim (German)
3-Thiabutan-2-one, O-(methylcarbamoyl)oxime
Acetimidic acid, N-((methylcarbamoyl)oxy)thio-, methyl ester (8CI)
Acetimidothioic acid, methyl-, N-(methylcarbamoyl) ester
DPX-X1179-412
Du Pont insecticide 1179
Dupont 1179
ENT 27,341
Ethanimidothioic acid, N-(((methylamino)carbonyl)oxy)-, methyl ester (9CI)
IN 1179
Insecticide 1,179
Lannate
Lannate 10L candidate
Lannate L
Lannate LV
Mesomile
Methomex
Methomyl
Methomyl (ACGIH)
Methyl N-(((methylamino)carbonyl)oxy)ethanimidothioate
Methyl O-(methylcarbamoyl)thiolacethohydroxamate
Methyl-N-((methylcarbamoyl)oxy)thioacetimidate
Metomil (Italian)
N-(((Methylamino)carbonyl)oxy)ethanimidothioic acid methyl ester
N-((Methylcarbamoyl)oxy)thioacetimidic acid methyl ester
NU-Bait II
Nudrin
RCRA waste number P066
SD 14999
S-Methyl N-(methylcarbamoyloxy) thioacetimidate
S-Methyl N-(methylcarbamoyloxy)thioacetimidate
WL 18236
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | lymphocyte/human | 180 µmol/L | EMMUEG 23,306,1994 |
Cytogenetic Analysis | oral/mouse | 20 mg/kg | ENVRAL 42,362,1987 |
Cytogenetic Analysis | ovary/hamster | 1.3 mg/L/2H | FCTOD7 45,928,2007 |
DNA Damage | other cell types/Drosophila melanogaster | 4 mmol/L/48H | FCTOD7 53,352,2013 |
DNA Damage | HeLa cell/human | 8 mmol/L/24H | FCTOD7 53,352,2013 |
DNA Damage | kidney/human | 8 mmol/L/24H | FCTOD7 53,352,2013 |
DNA Damage | HeLa cell/human | 8 mmol/L/30M | FCTOD7 53,352,2013 |
DNA Damage | intraperitoneal/mouse | 5 mg/kg | EMMUEG 24,235,1994 |
DNA Damage | intraperitoneal/mouse | 10 mg/kg | EMMUEG 24,235,1994 |
DNA Damage | lymphocyte/human | 500 µmol/L | EMMUEG 23,306,1994 |
DNA Damage | lymphocyte/human | 1 mmol/L | EMMUEG 23,306,1994 |
micronucleus test | lymphocyte/human | 10 µmol/L | EMMUEG 23,306,1994 |
mutation in microorganisms | /Saccharomyes cerevisiae | 50 ppm (-enzymatic activation step) | RSTUDV 6,161,1976 |
sperm morphology | oral/mouse | 20 mg/kg | ENVRAL 42,362,1987 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 32.5 mg/kg (65D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | FCTOD7 48,3221,2010 |
oral/rat | 32.5 mg/kg (65D male) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | FCTOD7 48,3221,2010 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, HeLa cell | Inhibitor Concentration (50 percent kill): 21.46 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | FCTOD7 53,352,2013 |
In Vitro/Human, HeLa cell | Inhibitor Concentration Low: 5 mmol/L/12H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | FCTOD7 53,352,2013 |
In Vitro/Human, kidney | Inhibitor Concentration Low: 10 mmol/L/12H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | FCTOD7 53,352,2013 |
In Vitro/Human, kidney | Inhibitor Concentration (50 percent kill): 8.2 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | FCTOD7 53,352,2013 |
In Vitro/ntb | Inhibitor Concentration Low: 10 mmol/L/12H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | FCTOD7 53,352,2013 |
In Vitro/ntb | Inhibitor Concentration (50 percent kill): 9.74 mmol/L/48H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | FCTOD7 53,352,2013 |
inhalation/duck | lethal concentration (50 percent kill): 1890 ppm | TXAPA9 40,1,1977 | |
inhalation/quail | lethal concentration (50 percent kill): 3680 ppm | TXAPA9 40,1,1977 | |
inhalation/rat | lethal concentration (50 percent kill): 77 ppm/4H | Eye: Lacrimation Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea | TXAPA9 40,1,1977 |
inhalation/rat | lethal concentration (50 percent kill): 450 mg/m3 | HBPTO* 2,1094,2001 | |
inhalation/rat | lethal concentration (50 percent kill): 0.3 gm/m3/4H | ENTOX* -,57,2005 | |
intraperitoneal/mouse | lowest published toxic dose: 5.2 mg/kg | Behavioral: Convulsions or effect on seizure threshold | TOSCF2 72,289,2003 |
intraperitoneal/mouse | lowest published lethal dose: 6.4 mg/kg | Behavioral: Convulsions or effect on seizure threshold | TOSCF2 72,289,2003 |
intraperitoneal/rat | lowest published toxic dose: 2.3 mg/kg | Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease | CTOXAO 47,725,2009 |
intraperitoneal/rat | lowest published toxic dose: 7.5 mg/kg | Brain and Coverings: Changes in surface EEG Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia | TXAPA9 219,122,2007 |
intraperitoneal/rat | lowest published toxic dose: 2.3 mg/kg | Lung, Thorax, or Respiration: Respiratory depression Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Body temperature decrease | TOXID9 -,444,2009 |
intraperitoneal/rat | lowest published toxic dose: 2.3 mg/kg | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease | FCLPH* 23(Suppl 1),8,2009 |
intraperitoneal/rat | lethal dose (50 percent kill): 6290 µg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Straub Tail | ETOPFR 7,119,1999 |
oral/chicken | lethal dose (50 percent kill): 28 mg/kg | Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | TXAPA9 40,1,1977 |
oral/chicken | lethal dose (50 percent kill): 28 mg/kg | ENTOX* -,57,2005 | |
oral/Dog | lethal dose (50 percent kill): 20 mg/kg | 85INA8 6,906,1991 | |
oral/duck | lethal dose (50 percent kill): 15 mg/kg | SHELL* | |
oral/guinea pig | lowest published lethal dose: 15 mg/kg | TXAPA9 40,1,1977 | |
oral/human | lowest published lethal dose: 12 mg/kg | Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1097,2001 |
oral/monkey | lowest published lethal dose: 40 mg/kg | TXAPA9 40,1,1977 | |
oral/mouse | lethal dose (50 percent kill): 10 mg/kg | JAFCAU 26,550,1978 | |
oral/pigeon | lethal dose (50 percent kill): 10 mg/kg | ASTTA8 (680),157,1979 | |
oral/quail | lethal dose (50 percent kill): 23700 µg/kg | ASTTA8 (680),157,1979 | |
oral/rat | lethal dose (50 percent kill): 12 mg/kg | HBPTO* 2,1094,2001 | |
oral/rat | lethal dose (50 percent kill): 20 mg/kg | Behavioral: Tremor Cardiac: Change in rate Skin and Appendages: Other: Sweating | FCTOD7 48,3221,2010 |
oral/rat | lowest published toxic dose: 0.6 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 44,395,2005 |
oral/rat | lowest published toxic dose: 0.1 mg/kg | Behavioral: Change in motor activity (specific assay) | TOXID9 44,397,2005 |
oral/rat | lowest published toxic dose: 0.25 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 331,1,2015 |
oral/wild bird | lethal dose (50 percent kill): 10 mg/kg | TXAPA9 21,315,1972 | |
skin/rabbit | lethal dose (50 percent kill): 556 mg/kg | HBPTO* 2,1094,2001 | |
skin/rat | lethal dose (50 percent kill): 1000 mg/kg | HBPTO* 2,1094,2001 | |
subcutaneous/rat | lethal dose (50 percent kill): 9 mg/kg | TXAPA9 25,569,1973 | |
unreported route/rat | lethal dose (50 percent kill): 17 mg/kg | VCVGK* -,512,1994 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/Dog | lowest published toxic dose: 18200 mg/kg/2Y- continuous | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in bone marrow not included in above Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 40,1,1977 |
oral/rat | lowest published toxic dose: 32.5 mg/kg/65D- intermittent | Endocrine: Androgenic Related to Chronic Data: Changes in prostate weight Related to Chronic Data: Changes in testicular weight | FCTOD7 48,3221,2010 |
oral/rat | lowest published toxic dose: 14700 µg/kg/5D- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | WDZAEK 6,37,1992 |
oral/rat | lowest published toxic dose: 102 mg/kg/60D- intermittent | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | JDGRAX 22,259,1998 |
oral/rat | lowest published toxic dose: 15960 mg/kg/95W- continuous | Blood: Changes in bone marrow not included in above Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | TXAPA9 40,1,1977 |
oral/rat | lowest published toxic dose: 264 mg/kg/33D- intermittent | Brain and Coverings: Other degenerative changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | CMSHAF 23,375,1991 |
oral/rat | lowest published toxic dose: 9 mg/kg/90D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JDGRAX 18,145,1989 |
skin/rabbit | lowest published toxic dose: 3 gm/kg/3W- intermittent | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 40,1,1977 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2.5 mg/m3 | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | MUREAV 557,109,2004 | |
TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
TOXICOLOGY REVIEW | ENTOX* -,57,2005 | |
TOXICOLOGY REVIEW | JTEHD6 7,1,2004 | |
TOXICOLOGY REVIEW | FEREAC 71,43906,2006 | |
TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
TOXICOLOGY REVIEW | FEREAC 73,47184,2008 | |
TOXICOLOGY REVIEW | MUTAEX 21,343,2006 | |
TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
TOXICOLOGY REVIEW | TXAPA9 258,309,2012 | |
TOXICOLOGY REVIEW | TOLED5 230,146,2014 | |
TOXICOLOGY REVIEW | MUREAV 767,67,2016 | |
TOXICOLOGY REVIEW | TXAPA9 268,157,2013 | |
TOXICOLOGY REVIEW | FCTOD7 83,300,2015 | |
TOXICOLOGY REVIEW | FCTOD7 105,456,2017 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,131,1998 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 2.5 mg/m3, JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 2.5 mg/m3;KZW 5 mg/m3, inhal, skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 2.5 mg/m3, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 2.5 mg/m3, skin, MAY2011 | |
Occupational Exposure Limit-FRANCE | VME 2.5 mg/m3, Skin, FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 2.5 mg/m3, skin, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 2.5 mg/m3, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 2.5 mg/m3, 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2.5 mg/m3, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 2.5 mg/m3, JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 2,5 mg/m3, JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 0.5 mg/m3, MAR2004 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 2.5 mg/m3, inhal, skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 2.5 mg/m3, Skin, 2003 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHOMYL-air | 10H time-weighted average 2.5 mg/m3 | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code B0027; Number of Industries 1; Total Number of Facilities 15; Number of Occupations 1; Total Number of Employees Exposed 2367; Total Number of Female Employees Exposed 1288 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health