Acetic acid, mercapto-

RTECS #

AI5950000

CAS #

68-11-1
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

92.12

Molecular Formula

C₂H₄O₂S

Synonyms

2-Mercaptoacetic acid
2-Thioglycolic acid
Acide thioglycolique (French)
alpha-Mercaptoacetic acid
Glycolic acid, 2-thio-
Glycolic acid, thio-
Kyselina merkaptooctova (Czech)
Kyselina thioglykolova (Czech)
Mercaptoacetate
Mercaptoacetic acid
Thioglycolic acid
Thioglycolic acid (ACGIH)
Thioglycollic acid
Thiovanic acid
USAF CB-35

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /human	3%		INMEAF 15,669,1946

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 8.3 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
inhalation/mouse	Lowest published lethal concentration: 7 mg/m³/2H		85GMAT -,111,1982
inhalation/rat	lethal concentration (50 percent kill): 210 mg/m³/4H	Behavioral: Food intake (animal) Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Changes in lung weight	NTIS** OTS0554077
intraperitoneal/guinea pig	lethal dose (50 percent kill): 157 mg/kg		ZHYGAM 20,575,1974
intraperitoneal/mouse	lethal dose (50 percent kill): 138 mg/kg		ARZNAD 31,1713,1981
intraperitoneal/rat	lethal dose (50 percent kill): 70 mg/kg		ZHYGAM 20,575,1974
intravenous/mouse	lethal dose (50 percent kill): 145 mg/kg		NYKZAU 60,278,1964
intravenous/rabbit	lethal dose (50 percent kill): 100 mg/kg		BIJOAK 41,325,1947
oral/guinea pig	lethal dose (50 percent kill): 126 mg/kg		34ZIAG -,586,1969
oral/mammal (species unspecified)	lethal dose (50 percent kill): 250 mg/kg		GISAAA 39(4),86,1974
oral/mouse	lethal dose (50 percent kill): 242 mg/kg		ZHYGAM 20,575,1974
oral/rabbit	lethal dose (50 percent kill): 119 mg/kg		ZHYGAM 20,575,1974
oral/rat	lethal dose (50 percent kill): 114 mg/kg		ZHYGAM 20,575,1974
skin/mouse	lethal dose (50 percent kill): 47 mg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold	SRTCAC 36(1-4),10,1989
skin/rabbit	lowest published lethal dose: 300 mg/kg	Skin: After systemic exposure: Dermatitis, other	GTPZAB 13(1),48,1969

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
subcutaneous/guinea pig	lowest published toxic dose: 210 mg/kg/14D- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Change in psychophysiological tests	TXAPA9 177,103,2001
subcutaneous/guinea pig	lowest published toxic dose: 105 mg/kg/7D- intermittent	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay)	TXAPA9 177,103,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 ppm (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FCTOD7 55,596,2013
TOXICOLOGY REVIEW		REPTED 58,252,2015
TOXICOLOGY REVIEW		RTOPDW 55,43,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (3.8 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 1 ppm (4 mg/m³);KZW 2 ppm (8 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (3.9 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 ppm (5 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1 ppm (3.8 mg/m³), short term exposure limit 3 ppm (11 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 1 ppm (5 mg/m³), Skin, FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 4 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 1 ppm (5 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 ppm (4 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1 ppm (5 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 ppm (3.8 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 ppm (5 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1 ppm (3.8 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.1 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 1 ppm (4 mg/m³);short term exposure limit 2 ppm (8 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 1 ppm (4 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 4 mg/m³, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 ppm (3.8 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THIOGLYCOLIC ACID-air	10H time-weighted average 1 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 83835; Number of Industries 10; Total Number of Facilities 2428; Number of Occupations 12; Total Number of Employees Exposed 30055; Total Number of Female Employees Exposed 15141
National Occupational Hazard Survey 1974	Hazard Code 83835; Number of Industries 10; Total Number of Facilities 5167; Number of Occupations 9; Total Number of Employees Exposed 35238

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health