Acetic acid, butyl ester

RTECS #

AF7350000

CAS #

123-86-4
See: NMAM or OSHA Methods

Updated

December 2017

Molecular Weight

116.18

Molecular Formula

C₆H₁₂O₂

Synonyms

1-Butyl acetate
Acetate de butyle (French)
Acetic acid n-butyl ester
Butile (acetati di) (Italian)
Butyl acetate (OSHA)
Butyl ethanoate
Butylacetat (German)
Butylacetaten (Dutch)
Butyle (acetate de) (French)
Butylester kyseliny octove (Czech)
n-Butyl acetate
n-Butyl acetate (ACGIH:OSHA)
Octan n-butylu (Polish)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	300 ppm		JIHTAB 25,282,1943
eye /rabbit	100 mg	moderate	ATDAEI 1,196,1992
skin /rabbit	500 mg/24H	moderate	FCTXAV 17,515,1979

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	1500 ppm/7H (7-16D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	NTIS** PB83-258038
inhalation/rat	1500 ppm (6-20D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	JAPTO* 27,32,2007
inhalation/rat	1500 ppm (21D pre-16D pregnant)	Reproductive: Other effects on female	HPV112 -,-,2008
inhalation/rabbit	1500 ppm (1-19D pregnant)	Reproductive: Other effects on female	HPV112 -,-,2008

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	Lowest published lethal concentration: 68 gm/m³/72M	Behavioral: General anesthetic Gastrointestinal: Changes in structure or function of salivary glands Lung, Thorax, or Respiration: Emphysema	AGGHAR 5,1,1933
inhalation/guinea pig	Lowest published lethal concentration: 67 gm/m³/4H	Eye: Other eye effects Behavioral: Antipsychotic	FCTXAV 17,515,1979
inhalation/human	lowest published toxic concentration: 200 ppm	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes	JIHTAB 25,282,1943
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 40 gm/m³		GTPZAB 32(10),25,1988
inhalation/mouse	lethal concentration (50 percent kill): 6 gm/m³/2H		YKYUA6 32,1241,1981
inhalation/rat	lethal concentration (50 percent kill): 390 ppm/4H	Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage	INHTE5 9,623,1997
intramuscular/guinea pig	lowest published lethal dose: 2648 mg/kg	Behavioral: Muscle weakness	JPETAB 76,189,1942
intraperitoneal/guinea pig	lowest published lethal dose: 1500 mg/kg	Liver: Fatty liver degeneration Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	AIHAAP 35,21,1974
intraperitoneal/mouse	lethal dose (50 percent kill): 1230 mg/kg		SCCUR* -,2,1961
oral/guinea pig	lethal dose (50 percent kill): 4700 mg/kg		85GMAT -,28,1982
oral/mammal (species unspecified)	lethal dose (50 percent kill): 4300 mg/kg		GTPZAB 32(10),25,1988
oral/mouse	lethal dose (50 percent kill): 6 gm/kg		GTPZAB 25(11),57,1981
oral/rabbit	lethal dose (50 percent kill): 3200 mg/kg		85GMAT -,28,1982
oral/rat	lethal dose (50 percent kill): 10768 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Liver: Other changes	ATDAEI 1,196,1992
skin/rabbit	lethal dose (50 percent kill): >17600 mg/kg		NPIRI* 1,7,1974
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 1592 mg/kg		GISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 1500 ppm/6H/13W- intermittent	Behavioral: Somnolence (general depressed activity) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 36(1 Pt2),61,1997
inhalation/rat	lowest published toxic concentration: 1500 ppm/6H/13W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight Endocrine: Changes in adrenal weight	FCTOD7 39,877,2001
inhalation/rat	lowest published toxic concentration: 3000 ppm/6H/13W- continuous	Brain and Coverings: Changes in brain weight Endocrine: Changes in spleen weight Endocrine: Changes in adrenal weight	FCTOD7 39,877,2001
inhalation/rat	lowest published toxic concentration: 1500 ppm/6H/13W- continuous	Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 39,877,2001
inhalation/rat	lowest published toxic concentration: 3000 ppm/6H/13W- continuous	Olfaction: Other olfaction effects	FCTOD7 39,877,2001
inhalation/rat	lowest published toxic concentration: 1500 ppm/6H/30D- continuous	Nutritional and Gross Metabolic: Changes in: Na Nutritional and Gross Metabolic: Changes in: Cl	FCTOD7 39,877,2001
inhalation/rat	lowest published toxic concentration: 3000 ppm/6H/30D- continuous	Nutritional and Gross Metabolic: Changes in: Na	FCTOD7 39,877,2001
inhalation/rat	lowest published toxic concentration: 1500 ppm/6H/90D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	FCTOD7 39,877,2001
inhalation/rat	lowest published toxic concentration: 3000 ppm/6H/90D- continuous	Blood: Changes in erythrocyte (RBC) count	FCTOD7 39,877,2001
inhalation/rat	lowest published toxic concentration: 3000 ppm/6H/90D- continuous	Blood: Changes in erythrocyte (RBC) count Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	FCTOD7 39,877,2001
inhalation/rat	lowest published toxic concentration: 83.8 gm/kg/13W- intermittent	Behavioral: Somnolence (general depressed activity) Endocrine: Changes in spleen weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 66,101,2002
inhalation/rat	lowest published toxic concentration: 2000 ppm/7D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JAPTO* 27,32,2007
inhalation/rat	lowest published toxic concentration: 1000 ppm/7D- intermittent	Behavioral: Food intake (animal)	JAPTO* 27,32,2007
inhalation/rat	lowest published toxic concentration: 1500 ppm/13W- intermittent	Olfaction: Other olfaction effects Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV112 -,-,2008
inhalation/rat	lowest published toxic concentration: 3000 ppm/14W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV112 -,-,2008

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 150 ppm;short term exposure limit 200 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		AMIHAB 21,28,1960
TOXICOLOGY REVIEW		MUREAV 564,179,2004
TOXICOLOGY REVIEW		HUTOX* -,649,1996
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		TOLED5 199,203,2010
TOXICOLOGY REVIEW		NETEEC 52,68,2015

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 150 ppm (700 mg/m³)	DTLVS* 3,30,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 150 ppm (713 mg/m³), short term exposure limit 200 ppm (950 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 150 ppm(723 mg/m³), short term exposure limit 200 ppm(964 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 150 ppm (710 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 150 ppm (720 mg/m³), short term exposure limit 200 ppm (960 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 150 ppm (710 mg/m³), VLE 200 ppm (940 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 100 ppm (480 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 950 mg/m³, short term exposure limit 950 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 150 ppm (700 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 100 ppm (475 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 150 ppm (710 mg/m³), short term exposure limit 200 ppm (950 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 150 ppm (710 mg/m³);short term exposure limit 200 ppm (950 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 150 ppm (713 mg/m³); short term exposure limit 200 ppm (950 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 75 ppm (355 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 150 ppm (713 mg/m³); short term exposure limit 200 ppm (950 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 200 mg/m³, MAC(short term exposure limit) 950 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 50 mg/m³, short term exposure limit 200 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 100 ppm (500 mg/m³);short term exposure limit 150 ppm (700 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 100 ppm (480 mg/m³), KZG-week 200 ppm (960 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 710 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 150 ppm (710 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 150 ppm (710 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 150 ppm (724 mg/m³);short term exposure limit 200 ppm (966 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 150 ppm (710 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 150 ppm (710 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 150 ppm (710 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 150 ppm (710 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-BUTYL ACETATE-air	10H time-weighted average 150 ppm;short term exposure limit 200 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 14380; Number of Industries 271; Total Number of Facilities 55011; Number of Occupations 164; Total Number of Employees Exposed 822099; Total Number of Female Employees Exposed 143606
National Occupational Hazard Survey 1974	Hazard Code 14380; Number of Industries 280; Total Number of Facilities 52224; Number of Occupations 153; Total Number of Employees Exposed 527992

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450
NIOSH Analytical Method, 1996: Volatile organic compound, 2549

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health