Preliminary Flu Vaccine Effectiveness (VE) Data for 2023-2024

At a glance

Tables showing preliminary flu vaccine effectiveness data for the 2023-2024 season.

Inclusion Dates by Network

Network

Dates

October 1, 2023– February 2, 2024

October 10, 2023–January 24, 2024

Flu Vaccine Effectiveness for Children

Number and percentage of children (6 months to 17 years) receiving seasonal influenza vaccine and vaccine effectiveness Aby influenza type and subtypeB— three networks, United States, 2023–24 influenza season

Network (Setting) Influenza positive
N vaccinated / Total (%)
Influenza negative
N vaccinated / Total (%)
VE (95% CI)*
Any Influenza
NVSN** (Outpatient***) 123/622 (20%) 793/2577 (31%) 59 (48–67)
US Flu VE (Outpatient) 29/283 (10%) 182/736 (25%) 67 (48–80)
VISION (Outpatient) 961/6068 (16%) 4579/15274 (30%) 60 (57–64)
NVSN (Inpatient) 29/128 (23%) 543/1321 (41%) 61 (40–75)
VISION (Inpatient) 21/113 (19%) 299/921 (32%) 52 (16–72)
Any Influenza A
NVSN (Outpatient) 84/411 (20%) 793/2577 (31%) 55 (41–66)
US Flu VE (Outpatient) 27/212 (13%) 182/736 (25%) 46 (15–67)
VISION (Outpatient) 920/5524 (17%) 4579/15274 (30%) 59 (55–62)
NVSN (Inpatient) 25/102 (25%) 543/1321 (41%) 56 (30–73)
VISION (Inpatient) 21/105 (20%) 299/921 (32%) 46 (7–69)
Influenza A(H1N1)pdm09
NVSN (Outpatient) 61/298 (20%) 793/2577 (31%) 54 (37–66)
US Flu VE (Outpatient) 11/120 (9%) 182/736 (25%) 61 (26–81)
NVSN (Inpatient) 18/79 (23%) 543/1321 (41%) 60 (32–77)
Influenza A(H3N2)
 NVSN (Outpatient) 19/87 (22%) 793/2577 (31%) 55 (20–74)
US Flu VE (Outpatient) 2/17 (12) 182/736 (25%)
NVSN (Inpatient) 4/10 (40%) 543/1321 (41%)
Influenza B
NVSN (Outpatient) 39/216 (18%) 793/2577 (31%) 64 (47–75)
US Flu VE (Outpatient) 3/76 (4%) 182/736 (25%) 89 (70–97)
VISION (Outpatient) 45/571 (8%) 4579/15274 (30%) 79 (71–85)
NVSN (Inpatient) 4/27 (15%) 543/1321 (41%)
VISION (Inpatient) 0/10 (0%) 299/921 (32%)

*All networks adjusted for geographic region, age, calendar time. US Flu VE and VISION adjusted for sex and race/ethnicity. US Flu VE also adjusted for time since illness onset and self-reported health status. VE estimates with fewer than 50 cases or from models that did not converge are not presented and are represented with a "—"

**Patients enrolled as outpatients in NVSN may have progressed to a more acute level of care, and those data may not be reflected in this analysis.

***Outpatient is defined as outpatient clinics, urgent care, and emergency departments for NVSN and US Flu VE. Outpatient is defined as urgent care and emergency departments for VISION.

Flu Vaccine Effectiveness for Adults

Number and percentage of adults (≥18 years) receiving seasonal influenza vaccine and vaccine effectivenessA by influenza type and subtypeB— three networks, United States, 2023–24 influenza season

Network (Setting) Influenza positive
N vaccinated / Total (%)
Influenza negative
N vaccinated / Total (%)
VE (95% CI)*
All adults (aged ≥18 years)
Any Influenza
US Flu VE (Outpatient**) 177/568 (31%) 803/1807 (44%) 33 (16–47)
VISION (Outpatient) 4501/18385 (24%) 21356/52657 (41%) 49 (47 –51)
IVY (Inpatient) 200/632 (32%) 1517/3872 (39%) 44 (32–54)
VISION (Inpatient) 728/1839 (40%) 7425/14168 (52%) 41 (34–47)
Any Influenza A
US Flu VE (Outpatient) 168/495 (34%) 803/1807 (44%) 27 (9–43)
VISION (Outpatient) 4343/15896 (27%) 21356/52657 (41%) 46 (44–48)
IVY (Inpatient) 80/264 (30%) 1517/3872 (39%) 42 (23–57)
VISION (Inpatient) 713/1742 (41%) 7425/14168 (52%) 40 (33–47)
Influenza A(H1N1)pdm09
US Flu VE (Outpatient) 111/308 (36%) 803/1807 (44%) 25 (1–43)
IVY (Inpatient) 58/209 (28%) 1517/3872 (39%) 50 (30–64)
Influenza A(H3N2)
US Flu VE (Outpatient) 14/67 (21%) 803/1807 (44%) 54 (11–77)
IVY (Inpatient) 18/45 (40%) 1517/3872 (39%)
Influenza B
US Flu VE (Outpatient) 9/76 (12%) 803/1807 (44%) 78 (57–90)
VISION (Outpatient) 164/2530 (6%) 21356/52657 (41%) 78 (74–81)
IVY (Inpatient) 5/21 (24%) 1517/3872 (39%)
VISION (Inpatient) 18/103 (17%) 7425/14168 (52%)  60 (30–77)
Adults (aged 18–64 years)
Any Influenza
US Flu VE (Outpatient) 136/489 (29%) 503/1368 (37%) 25 (4–42)
VISION (Outpatient) 2557/14698 (17%) 9194/33086 (28%) 52 (50–55)
IVY (Inpatient) 87/383 (23%) 579/1927 (30%) 49 (33–61)
VISION (Inpatient) 197/773 (25%) 1367/4050 (34%) 40 (28–50)
Any Influenza A
US Flu VE (Outpatient) 128/417 (31%) 503/1368 (37%) 13 (-13–34)
VISION (Outpatient) 2425/12294 (20%) 9194/33086 (28%) 49 (46–51)
IVY (Inpatient) 37/156 (24%) 579/1927 (30%) 42 (13–61)
VISION (Inpatient) 187/694 (27%) 1367/4050 (34%) 38 (24–48)
Influenza B
US Flu VE (Outpatient) 8/75 (11%) 503/1368 (37%) 75 (50–89)
VISION (Outpatient) 135/2433 (6%) 9194/33086 (28%) 79 (75–82)
IVY (Inpatient) 2/16 (12%) 579/1927 (30%)
VISION (Inpatient) 13/83 (16%) 1367/4050 (34%)  50 (5–74)
Older adults (aged ≥65 years)
Any Influenza
US Flu VE (Outpatient) 41/79 (52%) 300/439 (68%) 51 (14–72)
VISION (Outpatient) 1944/3687 (53%) 12162/19571 (62%) 41 (36–45)
IVY (Inpatient) 113/249 (45%) 938/1945 (48%) 42 (23–56)
VISION (Inpatient) 531/1066 (50%) 6058/10118 (60%) 42 (34–50)
Any Influenza A
US Flu VE (Outpatient) 40/78 (51%) 300/439 (68%) 52 (16–73)
VISION (Outpatient) 1918/3602 (53%) 12162/19571 (62%) 40 (36–45)
IVY (Inpatient) 43/108 (40%) 938/1945 (48%) 47 (19–65)
VISION (Inpatient) 526/1048 (50%) 6058/10118 (60%) 42 (34–49)
Influenza B
US Flu VE (Outpatient) 1/1 (100%) 300/439 (68%)
VISION (Outpatient) 29/97 (30%) 12162/19571 (62%)  69 (51–80)
IVY (Inpatient) 3/5 (60%) 938/1945 (48%)
VISION (Inpatient) 5/20 (25%) 6058/10118 (60%)

*All networks adjusted for geographic region, age, calendar time. IVY, US Flu VE, and VISION, adjusted for sex and race/ethnicity. US Flu VE also adjusted for time since illness onset and self-reported health status. VE estimates with fewer than 50 cases or from models that did not converge are not presented and are represented with a "—"

**Outpatient is defined as outpatient clinics, urgent care, and emergency departments for US Flu VE. Outpatient is defined as urgent care and emergency departments for VISION.

  1. VE was estimated using the test-negative design comparing vaccination odds among persons who tested positive for influenza to vaccination odds among persons who tested negative for any influenza and SARS-CoV-2. Calculated as (1 − adjusted OR ) × 100%; ORs were estimated using logistic regression. Firth logistic regression was used for NVSN’s inpatient estimates.
  2. Subtype was not available for VISION