What's New Archives - June 6, 2022

What to know

  • CDC has published updated tables for Ethylene Oxide Hemoglobin Adduct (ETHOX) in the Report.
  • Tables were temporarily withdrawn on April 5, 2022, but have now been re-released.
  • Update reflects the correction of a calibrator bias in the ETHOX measurement for NHANES cycles 2013-14 and 2015-16 by NCHS.
  • Updated tables can be found in the "Analysis of Whole Blood, Serum, and Urine Samples" section for NHANES cycles 1999-2018.
  • They provide ETHOX data for non-smokers from 2013-2016.
Decorative: what's new

Updated Ethylene Oxide Hemoglobin Adduct Data Tables Published

CDC has published updated tables for Ethylene Oxide Hemoglobin Adduct (NHANES variable name: ETHOX) in the National Report on Human Exposure to Environmental Chemicals following their temporary withdrawal on April 5, 2022.

The updated tables reflect the National Center for Health Statistics' (NCHS) re-release of Ethylene Oxide Hemoglobin Adduct data files following correction of a calibrator bias in the ETHOX measurement impacting National Health and Nutrition Examination Survey (NHANES) cycles 2013-14 and 2015-16.

The updated tables and their associated NHANES cycles are:

  • Analysis of Whole Blood, Serum, and Urine Samples, NHANES 1999-2018
  • Ethylene Oxide Hemoglobin Adduct in Non-smokers (2013 – 2016)
  • Ethylene Oxide Hemoglobin Adduct in Smokers (2013 – 2016)

Ethylene Oxide Hemoglobin Adduct in Non-smokers (2013 - 2016)

CAS Number 75-21-8
Geometric mean and selected percentiles of hemoglobin adduct concentrations of (in pmol/g hemoglobin) for the non-smoking^ U.S. population from the National Health and Nutrition Examination Survey.
Demographic (Categories) Survey
(Years)		 Geometric Mean
(95% CI)		 50th Percentile
(95% CI)		 75th Percentile
(95% CI)		 90th Percentile
(95% CI)		 95th Percentile
(95% CI)		 Sample
Size
Total population 13-14 28.5 (27.0-30.1) 29.1 (27.6-30.5) 37.5 (35.4-39.7) 50.1 (46.8-52.9) 60.8 (55.9-69.7) 1945
Total population 15-16 27.7 (26.1-29.5) 26.5 (25.2-27.7) 34.7 (32.7-36.6) 47.8 (44.0-53.4) 63.8 (54.0-80.1) 1896
Age 6-11 years 13-14 33.9 (31.6-36.4) 33.2 (30.2-36.8) 42.9 (37.9-47.9) 52.6 (48.8-56.2) 62.9 (55.8-76.1) 321
Age 6-11 years 15-16 33.1 (31.8-34.4) 32.2 (30.7-33.7) 39.9 (37.8-42.0) 52.0 (46.6-58.6) 60.3 (56.0-64.2) 301
Age 12-19 years 13-14 29.3 (27.4-31.2) 29.6 (27.4-31.2) 36.4 (34.4-40.0) 49.0 (44.1-56.8) 60.3 (48.0-79.8) 358
Age 12-19 years 15-16 27.6 (25.1-30.3) 27.0 (25.2-29.3) 35.3 (31.3-39.1) 46.3 (40.7-53.9) 54.0 (46.3-60.4) 328
Age 20+ years 13-14 27.8 (26.2-29.5) 28.6 (26.9-30.1) 36.8 (34.6-38.8) 49.2 (44.5-54.1) 60.8 (54.1-69.7) 1266
Age 20+ years 15-16 27.2 (25.5-29.0) 25.7 (24.1-27.2) 33.7 (32.0-36.2) 47.5 (43.1-54.0) 65.8 (54.0-82.7) 1267
Males 13-14 29.0 (27.2-31.0) 30.2 (28.3-31.3) 38.4 (35.9-40.4) 50.5 (45.3-52.9) 60.4 (52.9-71.1) 897
Males 15-16 29.1 (27.5-30.8) 27.3 (25.7-28.7) 36.4 (34.4-37.8) 51.2 (45.8-56.9) 80.1 (60.5-83.0) 882
Females 13-14 28.1 (26.5-29.8) 28.6 (26.9-29.7) 36.6 (34.9-38.6) 49.6 (45.7-55.6) 60.8 (54.7-69.7) 1048
Females 15-16 26.6 (24.7-28.6) 25.8 (24.1-27.3) 33.2 (31.7-35.6) 46.6 (40.5-52.6) 56.9 (49.0-68.1) 1014
Non-Hispanic blacks 13-14 31.3 (29.1-33.7) 30.8 (28.7-33.7) 43.9 (38.0-47.9) 58.3 (51.7-69.2) 78.4 (61.9-109) 376
Non-Hispanic blacks 15-16 31.8 (30.1-33.6) 30.7 (28.0-33.6) 40.6 (38.0-44.4) 53.9 (47.6-63.7) 65.6 (55.2-79.2) 340
Non-Hispanic whites 13-14 27.2 (25.0-29.5) 28.1 (26.2-30.2) 35.9 (32.6-39.1) 48.0 (42.1-52.9) 59.2 (49.6-69.7) 680
Non-Hispanic whites 15-16 26.1 (24.0-28.4) 25.0 (23.6-26.6) 32.2 (29.7-34.3) 43.1 (39.9-48.9) 63.8 (46.4-83.1) 569
All Hispanics 13-14 30.2 (28.9-31.6) 30.0 (29.2-31.3) 37.2 (35.1-39.5) 49.1 (44.4-53.7) 59.2 (52.6-73.1) 585
All Hispanics 15-16 29.0 (27.7-30.4) 27.6 (26.4-29.4) 35.7 (34.1-37.4) 47.4 (42.0-58.3) 62.7 (49.4-95.4) 654
Limit of detection (LOD, see Data Analysis section) for Survey years 13-14 and 15-16 are 13.13 and 13.13, respectively.
^ Non-smoking is defined as a serum cotinine concentration of 10 ng/mL or less.

Ethylene Oxide Hemoglobin Adduct in Smokers (2013 - 2016)

CAS Number 75-21-8
Geometric mean and selected percentiles of hemoglobin adduct concentrations (in pmol/g hemoglobin) for the cigarette smoking population* from the National Health and Nutrition Examination Survey.
Demographic (Categories) Survey
(Years)		 Geometric Mean
(95% CI)		 50th Percentile
(95% CI)		 75th Percentile
(95% CI)		 90th Percentile
(95% CI)		 95th Percentile
(95% CI)		 Sample
Size
Total population 13-14 199 (177-224) 227 (208-244) 354 (325-391) 526 (464-612) 676 (610-894) 416
Total population 15-16 192 (160-230) 228 (191-258) 374 (308-419) 533 (458-585) 675 (577-800) 377
Age 18-49 years 13-14 197 (175-221) 215 (177-250) 354 (314-399) 535 (439-649) 725 (535-926) 271
Age 18-49 years 15-16 151 (113-202) 180 (135-243) 296 (246-387) 464 (341-585) 585 (446-754) 220
Age 50+ years 13-14 204 (155-268) 243 (183-306) 345 (304-438) 510 (438-675) 657 (447-1250) 145
Age 50+ years 15-16 290 (245-342) 300 (228-381) 444 (375-565) 606 (513-806) 806 (577-1530) 157
Males 13-14 200 (174-229) 214 (182-250) 383 (307-438) 578 (435-747) 742 (578-1060) 231
Males 15-16 176 (133-234) 227 (175-272) 360 (294-446) 540 (452-604) 606 (569-685) 231
Females 13-14 199 (159-248) 230 (185-264) 335 (290-388) 503 (404-649) 651 (490-926) 185
Females 15-16 214 (179-256) 228 (173-266) 383 (296-432) 531 (392-922) 763 (434-1530) 146
Limit of detection (LOD, see Data Analysis section) for Survey years 13-14 and 15-16 are 13.13 and 13.13, respectively.
*Cigarette Smoking is defined as a serum cotinine concentration more than 10 ng/mL in participants from the National Health and Nutrition Examination Survey, excluding those who used other tobacco products.
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Content Source:
National Center for Environmental Health; Division of Laboratory Sciences